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Gene Review

CTDSP2  -  CTD (carboxy-terminal domain, RNA...

Homo sapiens

Synonyms: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2, NIF2, NLI-interacting factor 2, Nuclear LIM interactor-interacting factor 2, OS4, ...
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Disease relevance of CTDSP2

  • These results demonstrate that the highly conserved OS4 gene is frequently included in the 12q13-q15 amplicon and may contribute to the development of a subset of sarcomas [1].
  • Here, we report characterization of the full length OS4 cDNA derived from 12q13-q15 (Su et al., Proc. Natl. Acad. Sci. USA, 91: 9121-9125, 1994), a region frequently amplified in sarcomas and brain tumors [1].

High impact information on CTDSP2

  • The four PSRPs in spinach plastid 30 S ribosomal subunit (PSRP-1, 26.8 kDa, pI 6.2; PSRP-2, 21.7 kDa, pI 5.0; PSRP-3, 13.8 kDa, pI 4.9; PSRP-4, 5.2 kDa, pI 11.8) comprise 16% (67.6 kDa) of the total protein mass of the 30 S subunit (429.3 kDa) [2].
  • Furthermore, we detected OS4 amplification in 5/5 primary sarcomas with known amplification of the closely linked marker CDK4 [1].
  • We also observed overexpression of OS4 in three cancer cell lines with amplification of this gene [1].
  • Adjacent to the junction, the three most terminal repeats in the PSR2 array exhibited a higher sequence divergence relative to internal repeats, which is consistent with a theoretical prediction of the unequal exchange model for tandem repeat evolution [3].
  • Three families (PSR2, PSR18, PSR22) of related, tandemly repetitive DNAs were shown to be present solely on the PSR chromosome [4].

Associations of CTDSP2 with chemical compounds

  • The sequence of 20 of the amino-terminal amino acids of both NIF polypeptides is identical, but NIF-2 possesses an additional alanine at the amino-terminus [5].

Other interactions of CTDSP2


  1. Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas. Su, Y.A., Lee, M.M., Hutter, C.M., Meltzer, P.S. Oncogene (1997) [Pubmed]
  2. The plastid ribosomal proteins. Identification of all the proteins in the 30 S subunit of an organelle ribosome (chloroplast). Yamaguchi, K., von Knoblauch, K., Subramanian, A.R. J. Biol. Chem. (2000) [Pubmed]
  3. Evolution of tandemly repeated sequences: What happens at the end of an array? McAllister, B.F., Werren, J.H. J. Mol. Evol. (1999) [Pubmed]
  4. Molecular characterization of repetitive DNA sequences from a B chromosome. Eickbush, D.G., Eickbush, T.H., Werren, J.H. Chromosoma (1992) [Pubmed]
  5. Isolation of two polypeptides comprising the neutrophil-immobilizing factor of human leucocytes. Watt, K.W., Brightman, I.L., Goetzl, E.J. Immunology (1983) [Pubmed]
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