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Gene Review

SGK2  -  serum/glucocorticoid regulated kinase 2

Homo sapiens

Synonyms: H-SGK2, Serine/threonine-protein kinase Sgk2, Serum/glucocorticoid-regulated kinase 2, dJ138B7.2
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High impact information on SGK2

  • Like SGK1, the mRNA encoding SGK3 is expressed in all tissues examined, but SGK2 mRNA is only present at significant levels in liver, kidney and pancreas and, at lower levels, in the brain [1].
  • In this study, we determined that the two recently described isoforms, SGK2 and SGK3 are also expressed in renal cortical collecting duct (CCD) cells; however, their expression is not induced by aldosterone or glucocorticoids [2].
  • The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC [3].
  • In contrast, little is known about the transcriptional regulation of the two closely related isoforms SGK2 and SGK3, although they can be activated by phosphorylation [4].


  1. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Kobayashi, T., Deak, M., Morrice, N., Cohen, P. Biochem. J. (1999) [Pubmed]
  2. Regulation of sodium transport in mammalian collecting duct cells by aldosterone-induced kinase, SGK1: structure/function studies. Náray-Fejes-Tóth, A., Helms, M.N., Stokes, J.B., Fejes-Tóth, G. Mol. Cell. Endocrinol. (2004) [Pubmed]
  3. The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC. Friedrich, B., Feng, Y., Cohen, P., Risler, T., Vandewalle, A., Bröer, S., Wang, J., Pearce, D., Lang, F. Pflugers Arch. (2003) [Pubmed]
  4. Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Lang, F., Cohen, P. Sci. STKE (2001) [Pubmed]
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