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YPK2  -  Ypk2p

Saccharomyces cerevisiae S288c

Synonyms: Serine/threonine-protein kinase YPK2/YKR2, YKR2, YM9718.03C, YMR104C
 
 
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High impact information on YPK2

  • Ypk2 is phosphorylated directly by Tor2 in vitro, and Ypk2 activity is largely reduced in tor2Delta cells [1].
  • This truncation appears to partially disrupt an autoinhibitory domain in Ypk2, and a point mutation in this region (Ypk2(D239A)) conferred upon full-length Ypk2 the ability to rescue growth of cells compromised in TORC2, but not TORC1, function [1].
  • Screening for multicopy suppressors of tor2, we obtained a plasmid expressing an N-terminally truncated Ypk2 protein kinase [1].
  • The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9 [2].
  • A protein kinase-encoding gene, pkt1, from Trichoderma reesei, homologous to the yeast YPK1 and YPK2 (YKR2) genes [3].
 

Biological context of YPK2

  • Here we report the isolation and genetic characterization of a pair of previously described genes (YPK1 and YPK2) which are predicted to encode protein kinases that share 90% amino acid identity with each other and 44-46% identity with various isozymes of PKC throughout their putative catalytic domains [4].
  • A pair of putative protein kinase genes (YPK1 and YPK2) is required for cell growth in Saccharomyces cerevisiae [4].
  • The YPK1 gene was mapped to the left arm of chromosome XI and YPK2 was mapped to the right arm of chromosome XIII [4].
 

Anatomical context of YPK2

  • These kinases activate three AGC family kinases involved in the maintenance of cell wall integrity: Ypk1 and Ypk2, two closely related, functionally redundant enzymes (orthologues of mammalian protein kinase SGK), and Pkc1 (orthologue of mammalian protein kinase PRK2) [5].
 

Associations of YPK2 with chemical compounds

  • The encoded protein YKR2, containing 677 amino acids, shows about 40% sequence identity in the kinase region to a family of serine/threonine-specific protein kinases from various species [6].

References

  1. Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Kamada, Y., Fujioka, Y., Suzuki, N.N., Inagaki, F., Wullschleger, S., Loewith, R., Hall, M.N., Ohsumi, Y. Mol. Cell. Biol. (2005) [Pubmed]
  2. The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9. Liu, K., Zhang, X., Lester, R.L., Dickson, R.C. J. Biol. Chem. (2005) [Pubmed]
  3. A protein kinase-encoding gene, pkt1, from Trichoderma reesei, homologous to the yeast YPK1 and YPK2 (YKR2) genes. Morawetz, R., Mischak, H., Goodnight, J., Lendenfeld, T., Mushinsky, J.F., Kubicek, C.P. Gene (1994) [Pubmed]
  4. A pair of putative protein kinase genes (YPK1 and YPK2) is required for cell growth in Saccharomyces cerevisiae. Chen, P., Lee, K.S., Levin, D.E. Mol. Gen. Genet. (1993) [Pubmed]
  5. Differential roles of PDK1- and PDK2-phosphorylation sites in the yeast AGC kinases Ypk1, Pkc1 and Sch9. Roelants, F.M., Torrance, P.D., Thorner, J. Microbiology (Reading, Engl.) (2004) [Pubmed]
  6. A novel yeast gene coding for a putative protein kinase. Kubo, K., Ohno, S., Matsumoto, S., Yahara, I., Suzuki, K. Gene (1989) [Pubmed]
 
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