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Gene Review:

ZNF267 - zinc finger protein 267

Homo sapiens

Synonyms: HZF2, Zinc finger protein 267, Zinc finger protein HZF2

Schnabl, B. et al., Hu, K. et al.

Schnabl, Hu, Mühlbauer, Hellerbrand, Stefanovic, Brenner, Schölmerich,

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Disease relevance of ZNF267

In conclusion, our results suggest that the binding site for NF-Y is critical for ZNF267 gene regulation and, herewith, the activation of this transcriptional factor may play an important role in the activation process of HSCs and in liver fibrosis [1].

High impact information on ZNF267

Microarray analysis and RNase protection assays showed that ZNF267 represses MMP-10 gene expression, which was confirmed by reporter gene assays [2].
Furthermore, ZNF267 binds to the MMP-10 promoter region as demonstrated by chromatin immunoprecipitation assays [2].
ZNF267 belongs to the family of Kruppel-like zinc fingers and contains a conserved KRAB (Kruppel associated box) A and B domain in the N-terminal part outside the C-terminal region of zinc fingers [2].
Recently, ZNF267 has been shown to modulate gene expression and to function as a transcriptional repressor [1].
In co-transfection experiments, NF-YA increased the promoter activity of ZNF267 [1].

Biological context of ZNF267

The ZNF267 gene has a TATA-less promoter with multiple transcription initiation sites [1].

Other interactions of ZNF267

In conclusion, our results suggest that ZNF267 as a negative transcriptional regulator of MMP-10 might promote liver fibrogenesis through alteration of matrix degradation in vivo [2].

Analytical, diagnostic and therapeutic context of ZNF267

Using microarray analysis to identify genes differentially expressed during the activation process of human HSCs, zinc finger protein 267 (ZNF267) mRNA was up-regulated in activated HSCs and in cirrhotic human liver [2].

References

Characterization of the human zinc finger protein 267 promoter: essential role of nuclear factor Y. Hu, K., Fink, M., Froh, M., Gäbele, E., Hellerbrand, C., Mühlbauer, M., Wiest, R., Schölmerich, J., Schnabl, B. Biochim. Biophys. Acta (2005) [Pubmed]
Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Schnabl, B., Hu, K., Mühlbauer, M., Hellerbrand, C., Stefanovic, B., Brenner, D.A., Schölmerich, J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]

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ZNF267	Macaca mulatta
D3Ertd254e	Mus musculus
ZNF267	Pan troglodytes
Rslcan18	Rattus norvegicus

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