Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

CNPY2 - canopy FGF signaling regulator 2

Homo sapiens

Synonyms: Cnpy2, HP10390, MIR-interacting saposin-like protein, MSAP, Protein canopy homolog 2, ...

Bornhauser, B.C. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TMEM4

Overexpression of MSAP enhances neurite out-growth in neuroblastoma and PC12 cells, whereas down-regulation of MSAP using RNA silencing led to inhibition of neurite formation [1].

High impact information on TMEM4

The stimulation of neurite outgrowth by MSAP was abrogated by the overexpression of MIR, which induced a decrease in the levels of myosin regulatory light chain (MRLC) [1].
MSAP interacts with the ezrin-radixin-moesin (ERM)-like myosin regulatory light chain-interacting protein (MIR), and the two proteins are co-localized in cell lines and in primary neurons [1].

Anatomical context of TMEM4

MSAP can stabilize MRLC and thus bring about an increase in neurite outgrowth [1].

References

MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. Bornhauser, B.C., Olsson, P.A., Lindholm, D. J. Biol. Chem. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

CNPY2	Bos taurus
CNPY2	Canis lupus familiaris
cnpy2	Danio rerio
CNPY2	Gallus gallus
Cnpy2	Mus musculus
CNPY2	Pan troglodytes
Cnpy2	Rattus norvegicus
cnpy2	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.