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Gene Review

NPM2  -  nucleophosmin/nucleoplasmin 2

Homo sapiens

Synonyms: Nucleoplasmin-2
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High impact information on NPM2

  • In contrast to NPM1 and NPM-like proteins in invertebrates, NPM2 and NPM3 have a polyphyletic origin [1].
  • To investigate NPM2's role in radioresistance acquisition, we transfected HeLa cells with NPM2 cDNA and analyzed survival after irradiation of the clones obtained [2].
  • FBXW1 (betaTRCP1 or BTRC1)-FGF8-NPM3 locus at human chromosome 10q24.32, FBXW11 (betaTRCP2 or BTRC2)-FGF18-NPM1 locus at human chromosome 5q35.1, and FGF17-NPM2 locus at human chromosome 8p21.3 were paralogous regions within the human genome [3].
  • Four oocyte-specific genes (MATER, ZAR1, NPM2 and FIGLA) were detected in hGVO for the first time [4].

Biological context of NPM2


Anatomical context of NPM2

  • The nucleophosmin/nucleoplasmin (NPM) family of molecular chaperones encompasses members ubiquitously expressed in many somatic tissues (NPM1 and -3) or specific to oocytes and eggs (NPM2) [1].

Other interactions of NPM2

  • This variant encoded for a 35-amino acid truncated NPM (NPM2) [2].


  1. Long-term evolution and functional diversification in the members of the nucleophosmin/nucleoplasmin family of nuclear chaperones. Eirín-López, J.M., Frehlick, L.J., Ausió, J. Genetics (2006) [Pubmed]
  2. Increased expression of a COOH-truncated nucleophosmin resulting from alternative splicing is associated with cellular resistance to ionizing radiation in HeLa cells. Dalenc, F., Drouet, J., Ader, I., Delmas, C., Rochaix, P., Favre, G., Cohen-Jonathan, E., Toulas, C. Int. J. Cancer (2002) [Pubmed]
  3. Comparative genomics on FGF8, FGF17, and FGF18 orthologs. Katoh, M., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
  4. Distinct sets of developmentally regulated genes that are expressed by human oocytes and human embryonic stem cells. Zhang, P., Kerkelä, E., Skottman, H., Levkov, L., Kivinen, K., Lahesmaa, R., Hovatta, O., Kere, J. Fertil. Steril. (2007) [Pubmed]
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