High impact information on FIGLA

• Factor in the germline (Figla) and newborn ovary homeobox gene (Nobox) represent a growing number of oocyte-specific transcription factors that regulate genes unique to oocytes [1].
• These results suggest that FIGLA is involved in continued oocyte survival as primordial follicles form in the human as in the rodent ovary [2].
• PCR expression profiling of this transcript revealed FIGLA mRNA expression in cDNA derived from ovarian follicles (5/5 samples from the primordial through to the secondary stage) mature oocytes (6/9 samples), and less frequently in preimplantation embryos (2/7 samples) [3].
• In the present study, we have isolated full-length cDNA of S TRA8 and partial cDNAs of PIWIL2, FIGLA, TEX17, and TUBA7, and analyzed their expression patterns in human tissues [4].
• Four oocyte-specific genes (MATER, ZAR1, NPM2 and FIGLA) were detected in hGVO for the first time [5].

Biological context of FIGLA

• Germ cell-specific transcription factors such as Figla and Nobox are critical in oogenesis, while Zfp148 and Taf4b are also critical in spermatogenesis [6].

Anatomical context of FIGLA

• Isolation, characterization and expression of the human Factor In the Germline alpha (FIGLA) gene in ovarian follicles and oocytes [3].

Analytical, diagnostic and therapeutic context of FIGLA

• Standard and real-time RT-PCR demonstrated that the human FIGLA gene is expressed in the fetal ovary but not by a range of other tissues, and that expression increases across mid-gestation, rising some 40-fold by the time of primordial follicle formation [2].

References