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Gene Review

FIGLA  -  folliculogenesis specific basic helix-loop...

Homo sapiens

Synonyms: BHLHC8, Class C basic helix-loop-helix protein 8, FIGALPHA, FIGalpha, Factor in the germline alpha, ...
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High impact information on FIGLA

  • Factor in the germline (Figla) and newborn ovary homeobox gene (Nobox) represent a growing number of oocyte-specific transcription factors that regulate genes unique to oocytes [1].
  • These results suggest that FIGLA is involved in continued oocyte survival as primordial follicles form in the human as in the rodent ovary [2].
  • PCR expression profiling of this transcript revealed FIGLA mRNA expression in cDNA derived from ovarian follicles (5/5 samples from the primordial through to the secondary stage) mature oocytes (6/9 samples), and less frequently in preimplantation embryos (2/7 samples) [3].
  • In the present study, we have isolated full-length cDNA of S TRA8 and partial cDNAs of PIWIL2, FIGLA, TEX17, and TUBA7, and analyzed their expression patterns in human tissues [4].
  • Four oocyte-specific genes (MATER, ZAR1, NPM2 and FIGLA) were detected in hGVO for the first time [5].

Biological context of FIGLA


Anatomical context of FIGLA


Analytical, diagnostic and therapeutic context of FIGLA

  • Standard and real-time RT-PCR demonstrated that the human FIGLA gene is expressed in the fetal ovary but not by a range of other tissues, and that expression increases across mid-gestation, rising some 40-fold by the time of primordial follicle formation [2].


  1. Transcriptional regulation of early oogenesis: in search of masters. Pangas, S.A., Rajkovic, A. Hum. Reprod. Update (2006) [Pubmed]
  2. Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary. Bayne, R.A., Martins da Silva, S.J., Anderson, R.A. Mol. Hum. Reprod. (2004) [Pubmed]
  3. Isolation, characterization and expression of the human Factor In the Germline alpha (FIGLA) gene in ovarian follicles and oocytes. Huntriss, J., Gosden, R., Hinkins, M., Oliver, B., Miller, D., Rutherford, A.J., Picton, H.M. Mol. Hum. Reprod. (2002) [Pubmed]
  4. Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8. Miyamoto, T., Sengoku, K., Takuma, N., Hasuike, S., Hayashi, H., Yamauchi, T., Yamashita, T., Ishikawa, M. J. Assist. Reprod. Genet. (2002) [Pubmed]
  5. Distinct sets of developmentally regulated genes that are expressed by human oocytes and human embryonic stem cells. Zhang, P., Kerkelä, E., Skottman, H., Levkov, L., Kivinen, K., Lahesmaa, R., Hovatta, O., Kere, J. Fertil. Steril. (2007) [Pubmed]
  6. Sohlh2 is a germ cell-specific bHLH transcription factor. Ballow, D.J., Xin, Y., Choi, Y., Pangas, S.A., Rajkovic, A. Gene Expr. Patterns (2006) [Pubmed]
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