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Gene Review

FBXW11  -  F-box and WD repeat domain containing 11

Homo sapiens

Synonyms: BTRC2, BTRCP2, F-box and WD repeats protein beta-TrCP2, F-box/WD repeat-containing protein 11, F-box/WD repeat-containing protein 1B, ...
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Disease relevance of FBXW11

  • Holoprosencephaly and preaxial polydactyly associated with a 1.24 Mb duplication encompassing FBXW11 at 5q35.1 [1].
  • We selected the osteosarcoma MDR HosDXR150 cell line by culturing Hos cells in the presence of increasing doxorubicin doses and showed that it is crossresistant to vinblastine [2].
  • These antibiotics resulted in an increase (5- to 30-fold) in the susceptibility of a variety of CD4- human cell lines to infection by LAV-2/B (RD, HeLa, HT29, Rsb, Heb7a, Hos, and Daudi) [3].

High impact information on FBXW11


Analytical, diagnostic and therapeutic context of FBXW11

  • Likewise, RT-PCR revealed that Hos and MG63 cells expressed BMP-7 [5].


  1. Holoprosencephaly and preaxial polydactyly associated with a 1.24 Mb duplication encompassing FBXW11 at 5q35.1. Koolen, D.A., Herbergs, J., Veltman, J.A., Pfundt, R., van Bokhoven, H., Stroink, H., Sistermans, E.A., Brunner, H.G., Geurts van Kessel, A., de Vries, B.B. J. Hum. Genet. (2006) [Pubmed]
  2. Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes. La Sala, D., Macaluso, M., Trimarchi, C., Giordano, A., Cinti, C. Oncogene (2003) [Pubmed]
  3. Reduced glycosylation of human cell lines increases susceptibility to CD4-independent infection by human immunodeficiency virus type 2 (LAV-2/B). Talbot, S.J., Weiss, R.A., Schulz, T.F. J. Virol. (1995) [Pubmed]
  4. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Hart, M., Concordet, J.P., Lassot, I., Albert, I., del los Santos, R., Durand, H., Perret, C., Rubinfeld, B., Margottin, F., Benarous, R., Polakis, P. Curr. Biol. (1999) [Pubmed]
  5. Characterization of human bone morphogenetic protein (BMP)-4 and -7 gene promoters: activation of BMP promoters by Gli, a sonic hedgehog mediator. Kawai, S., Sugiura, T. Bone (2001) [Pubmed]
  6. Comparative genomics on FGF8, FGF17, and FGF18 orthologs. Katoh, M., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
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