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Gene Review

dapA  -  dihydrodipicolinate synthase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2474, JW2463
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Disease relevance of dapA


High impact information on dapA


Chemical compound and disease context of dapA


Biological context of dapA


Associations of dapA with chemical compounds


Analytical, diagnostic and therapeutic context of dapA


  1. Chromosomal location and nucleotide sequence of the Escherichia coli dapA gene. Richaud, F., Richaud, C., Ratet, P., Patte, J.C. J. Bacteriol. (1986) [Pubmed]
  2. L-Lysine biosynthetic pathway of Methylophilus methylotrophus and construction of an L-lysine producer. Tsujimoto, N., Gunji, Y., Ogawa-Miyata, Y., Shimaoka, M., Yasueda, H. J. Biotechnol. (2006) [Pubmed]
  3. Overproduction of L-Lysine from methanol by Methylobacillus glycogenes derivatives carrying a plasmid with a mutated dapA gene. Motoyama, H., Yano, H., Terasaki, Y., Anazawa, H. Appl. Environ. Microbiol. (2001) [Pubmed]
  4. Transgenic canola and soybean seeds with increased lysine. Falco, S.C., Guida, T., Locke, M., Mauvais, J., Sanders, C., Ward, R.T., Webber, P. Biotechnology (N.Y.) (1995) [Pubmed]
  5. Regulation of aspartokinase, aspartate semialdehyde dehydrogenase, dihydrodipicolinate synthase and dihydrodipicolinate reductase in Lactobacillus plantarum. Cahyanto, M.N., Kawasaki, H., Nagashio, M., Fujiyama, K., Seki, T. Microbiology (Reading, Engl.) (2006) [Pubmed]
  6. Organization and nucleotide sequence of the Bacillus subtilis diaminopimelate operon, a cluster of genes encoding the first three enzymes of diaminopimelate synthesis and dipicolinate synthase. Chen, N.Y., Jiang, S.Q., Klein, D.A., Paulus, H. J. Biol. Chem. (1993) [Pubmed]
  7. Functional rescue of a bacterial dapA auxotroph with a plant cDNA library selects for mutant clones encoding a feedback-insensitive dihydrodipicolinate synthase. Vauterin, M., Frankard, V., Jacobs, M. Plant J. (2000) [Pubmed]
  8. Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase. Dobson, R.C., Devenish, S.R., Turner, L.A., Clifford, V.R., Pearce, F.G., Jameson, G.B., Gerrard, J.A. Biochemistry (2005) [Pubmed]
  9. Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy. Blickling, S., Renner, C., Laber, B., Pohlenz, H.D., Holak, T.A., Huber, R. Biochemistry (1997) [Pubmed]
  10. Expression from the Escherichia coli dapA promoter is regulated by intracellular levels of diaminopimelic acid. Acord, J., Masters, M. FEMS Microbiol. Lett. (2004) [Pubmed]
  11. Regulation of enzymes of lysine biosynthesis in Corynebacterium glutamicum. Cremer, J., Treptow, C., Eggeling, L., Sahm, H. J. Gen. Microbiol. (1988) [Pubmed]
  12. A gene for a new lipoprotein in the dapA-purC interval of the Escherichia coli chromosome. Bouvier, J., Pugsley, A.P., Stragier, P. J. Bacteriol. (1991) [Pubmed]
  13. General organization of the genes specifically involved in the diaminopimelate-lysine biosynthetic pathway of Corynebacterium glutamicum. Yeh, P., Sicard, A.M., Sinskey, A.J. Mol. Gen. Genet. (1988) [Pubmed]
  14. Replacement of diaminopimelic acid by cystathionine or lanthionine in the peptidoglycan of Escherichia coli. Mengin-Lecreulx, D., Blanot, D., van Heijenoort, J. J. Bacteriol. (1994) [Pubmed]
  15. A new family of mobilizable suicide plasmids based on broad host range R388 plasmid (IncW) and RP4 plasmid (IncPalpha) conjugative machineries and their cognate Escherichia coli host strains. Demarre, G., Guérout, A.M., Matsumoto-Mashimo, C., Rowe-Magnus, D.A., Marlière, P., Mazel, D. Res. Microbiol. (2005) [Pubmed]
  16. Escherichia coli dihydrodipicolinate synthase. Identification of the active site and crystallization. Laber, B., Gomis-Rüth, F.X., Romão, M.J., Huber, R. Biochem. J. (1992) [Pubmed]
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