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Gene Review:

ung - uracil-DNA glycosylase

Escherichia coli CFT073

Lu, C.C. et al., Amado, L. et al., Huang, S. et al., Lari, S.U. et al.

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Disease relevance of ung

Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance [1].
Characterization of the uracil-DNA glycosylase activity of Epstein-Barr virus BKRF3 and its role in lytic viral DNA replication [2].

High impact information on ung

The low molecular weight of the replication intermediates is unchanged by blocking linear DNA processing with a recBCD mutation or by blocking uracil excision with an ung mutation [3].
In addition, BKRF3 was able to complement an E. coli ung mutant in rifampin and nalidixic acid resistance mutator assays [2].
In contrast, the ung and mutY mutants did not show higher frequencies of intergenomic recombination or greater sensitivity to UV-induced DNA damage than the wild type [4].

References

Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance. Lari, S.U., Chen, C.Y., Vert??ssy, B.G., Morr??, J., Bennett, S.E. DNA Repair (Amst.) (2006) [Pubmed]
Characterization of the uracil-DNA glycosylase activity of Epstein-Barr virus BKRF3 and its role in lytic viral DNA replication. Lu, C.C., Huang, H.T., Wang, J.T., Slupphaug, G., Li, T.K., Wu, M.C., Chen, Y.C., Lee, C.P., Chen, M.R. J. Virol. (2007) [Pubmed]
The replication intermediates in Escherichia coli are not the product of DNA processing or uracil excision. Amado, L., Kuzminov, A. J. Biol. Chem. (2006) [Pubmed]
Antimutator role of the DNA glycosylase mutY gene in Helicobacter pylori. Huang, S., Kang, J., Blaser, M.J. J. Bacteriol. (2006) [Pubmed]

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