Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CPQ - carboxypeptidase Q

Homo sapiens

Synonyms: Carboxypeptidase Q, LCH1, LDP, Lysosomal dipeptidase, PGCP, ...

Gingras, R. et al.

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High impact information on PGCP

PGCP showed significant amino acid sequence homology to several cocatalytic metallopeptidases including a glutamate carboxypeptidase II also known as N-acetyl-aspartyl-alpha-glutamate carboxypeptidase or as prostate-specific membrane antigen and expressed glutamate carboxypeptidase activity [1].
A PGCP cDNA was obtained as an expressed sequence tag clone and completed at 5'-end by rapid amplification of cDNA ends polymerase chain reaction [1].
Expression of the PGCP cDNA in COS-1 cells, followed by Western blotting and metabolic labeling showed that PGCP is synthesized as a 62-kDa precursor, which is processed to a 56-kDa mature form containing two Asn-linked oligosaccharide chains [1].
In humans, PGCP is found principally in blood plasma, suggesting a potential role in the metabolism of secreted peptides [1].

References

Purification, cDNA cloning, and expression of a new human blood plasma glutamate carboxypeptidase homologous to N-acetyl-aspartyl-alpha-glutamate carboxypeptidase/prostate-specific membrane antigen. Gingras, R., Richard, C., El-Alfy, M., Morales, C.R., Potier, M., Pshezhetsky, A.V. J. Biol. Chem. (1999) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP013078	Anopheles gambiae str. PEST
AgaP_AGAP001264	Anopheles gambiae str. PEST
AgaP_AGAP013443	Anopheles gambiae str. PEST
CPQ	Bos taurus
CPQ	Canis lupus familiaris
CPQ	Gallus gallus
CPQ	Macaca mulatta
Cpq	Mus musculus
CPQ	Pan troglodytes
Cpq	Rattus norvegicus
cpq	Xenopus (Silurana) tropicalis

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