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Gene Review

FOLH1  -  folate hydrolase (prostate-specific...

Homo sapiens

Synonyms: Cell growth-inhibiting gene 27 protein, FGCP, FOLH, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, ...
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Disease relevance of FOLH1


Psychiatry related information on FOLH1


High impact information on FOLH1


Chemical compound and disease context of FOLH1


Biological context of FOLH1


Anatomical context of FOLH1


Associations of FOLH1 with chemical compounds


Other interactions of FOLH1


Analytical, diagnostic and therapeutic context of FOLH1


  1. Expression pattern of mouse homolog of prostate-specific membrane antigen (FOLH1) in the transgenic adenocarcinoma of the mouse prostate model. Schmittgen, T.D., Zakrajsek, B.A., Hill, R.E., Liu, Q., Reeves, J.J., Axford, P.D., Singer, M.J., Reed, M.W. Prostate (2003) [Pubmed]
  2. Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity. Pangalos, M.N., Neefs, J.M., Somers, M., Verhasselt, P., Bekkers, M., van der Helm, L., Fraiponts, E., Ashton, D., Gordon, R.D. J. Biol. Chem. (1999) [Pubmed]
  3. Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk. Morin, I., Devlin, A.M., Leclerc, D., Sabbaghian, N., Halsted, C.H., Finnell, R., Rozen, R. Mol. Genet. Metab. (2003) [Pubmed]
  4. Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer. Mesters, J.R., Barinka, C., Li, W., Tsukamoto, T., Majer, P., Slusher, B.S., Konvalinka, J., Hilgenfeld, R. EMBO J. (2006) [Pubmed]
  5. Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene. O'Keefe, D.S., Su, S.L., Bacich, D.J., Horiguchi, Y., Luo, Y., Powell, C.T., Zandvliet, D., Russell, P.J., Molloy, P.L., Nowak, N.J., Shows, T.B., Mullins, C., Vonder Haar, R.A., Fair, W.R., Heston, W.D. Biochim. Biophys. Acta (1998) [Pubmed]
  6. Influence of radioimmunoscintigraphy on postprostatectomy radiotherapy treatment decision making. Jani, A.B., Blend, M.J., Hamilton, R., Brendler, C., Pelizzari, C., Krauz, L., Vijayakumar, S., Sapra, B., Awan, A., Weichselbaum, R.R. J. Nucl. Med. (2004) [Pubmed]
  7. Validation of the German prostate-specific module. Bestmann, B., Rohde, V., Siebmann, J.U., Galalae, R., Weidner, W., Küchler, T. World journal of urology. (2006) [Pubmed]
  8. Monitoring adult patients with sleep apnea. Kramer, B.M. Otolaryngol. Clin. North Am. (1990) [Pubmed]
  9. Crystal structure of the ectodomain of human transferrin receptor. Lawrence, C.M., Ray, S., Babyonyshev, M., Galluser, R., Borhani, D.W., Harrison, S.C. Science (1999) [Pubmed]
  10. Prospective analysis of prostate-specific markers in pelvic lymph nodes of patients with high-risk prostate cancer. Ferrari, A.C., Stone, N.N., Eyler, J.N., Gao, M., Mandeli, J., Unger, P., Gallagher, R.E., Stock, R. J. Natl. Cancer Inst. (1997) [Pubmed]
  11. Prostate-specific membrane antigen expression in the duodenum: implications in coeliac disease and immunotherapy for prostate cancer. Maraj, B.H., Aldersley, M.A., Markham, A.F. Lancet (1998) [Pubmed]
  12. Haematogenous dissemination of prostatic epithelial cells during radical prostatectomy. Eschwège, P., Dumas, F., Blanchet, P., Le Maire, V., Benoit, G., Jardin, A., Lacour, B., Loric, S. Lancet (1995) [Pubmed]
  13. Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. Devlin, A.M., Ling, E.H., Peerson, J.M., Fernando, S., Clarke, R., Smith, A.D., Halsted, C.H. Hum. Mol. Genet. (2000) [Pubmed]
  14. Novel role of prostate-specific membrane antigen in suppressing prostate cancer invasiveness. Ghosh, A., Wang, X., Klein, E., Heston, W.D. Cancer Res. (2005) [Pubmed]
  15. Expression of the prostate-specific membrane antigen. Israeli, R.S., Powell, C.T., Corr, J.G., Fair, W.R., Heston, W.D. Cancer Res. (1994) [Pubmed]
  16. Pilot trial of unlabeled and indium-111-labeled anti-prostate-specific membrane antigen antibody J591 for castrate metastatic prostate cancer. Morris, M.J., Divgi, C.R., Pandit-Taskar, N., Batraki, M., Warren, N., Nacca, A., Smith-Jones, P., Schwartz, L., Kelly, W.K., Slovin, S., Solit, D., Halpern, J., Delacruz, A., Curley, T., Finn, R., O'donoghue, J.A., Livingston, P., Larson, S., Scher, H.I. Clin. Cancer Res. (2005) [Pubmed]
  17. Effect of glutamate carboxypeptidase II and reduced folate carrier polymorphisms on folate and total homocysteine concentrations in dialysis patients. Födinger, M., Dierkes, J., Skoupy, S., Röhrer, C., Hagen, W., Puttinger, H., Hauser, A.C., Vychytil, A., Sunder-Plassmann, G. J. Am. Soc. Nephrol. (2003) [Pubmed]
  18. NFATc1 with AP-3 site binding specificity mediates gene expression of prostate-specific-membrane-antigen. Lee, S.J., Lee, K., Yang, X., Jung, C., Gardner, T., Kim, H.S., Jeng, M.H., Kao, C. J. Mol. Biol. (2003) [Pubmed]
  19. Effects of the glutamate carboxypeptidase II (GCP2 1561C>T) and reduced folate carrier (RFC1 80G>A) allelic variants on folate and total homocysteine levels in kidney transplant patients. Winkelmayer, W.C., Eberle, C., Sunder-Plassmann, G., Födinger, M. Kidney Int. (2003) [Pubmed]
  20. Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase. Carter, R.E., Feldman, A.R., Coyle, J.T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  21. A tissue-specific enhancer of the prostate-specific membrane antigen gene, FOLH1. Watt, F., Martorana, A., Brookes, D.E., Ho, T., Kingsley, E., O'Keefe, D.S., Russell, P.J., Heston, W.D., Molloy, P.L. Genomics (2001) [Pubmed]
  22. Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase. Davis, M.I., Bennett, M.J., Thomas, L.M., Bjorkman, P.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  23. Molecular Evolution of the Transferrin Receptor/Glutamate Carboxypeptidase II Family. Lambert, L.A., Mitchell, S.L. J. Mol. Evol. (2007) [Pubmed]
  24. Prostate epithelial cell lines form spheroids with evidence of glandular differentiation in three-dimensional Matrigel cultures. Lang, S.H., Sharrard, R.M., Stark, M., Villette, J.M., Maitland, N.J. Br. J. Cancer (2001) [Pubmed]
  25. Tumor cell targeted gene delivery by adenovirus 5 vectors carrying knobless fibers with antibody-binding domains. Henning, P., Andersson, K.M., Frykholm, K., Ali, A., Magnusson, M.K., Nygren, P.A., Granio, O., Hong, S.S., Boulanger, P., Lindholm, L. Gene Ther. (2005) [Pubmed]
  26. Genetic susceptibility to neural tube defect pregnancy varies with offspring phenotype. Relton, C.L., Wilding, C.S., Jonas, P.A., Lynch, S.A., Tawn, E.J., Burn, J. Clin. Genet. (2003) [Pubmed]
  27. Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Israeli, R.S., Powell, C.T., Fair, W.R., Heston, W.D. Cancer Res. (1993) [Pubmed]
  28. Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells. Pinto, J.T., Suffoletto, B.P., Berzin, T.M., Qiao, C.H., Lin, S., Tong, W.P., May, F., Mukherjee, B., Heston, W.D. Clin. Cancer Res. (1996) [Pubmed]
  29. Expression of prostate specific membrane antigen and three alternatively spliced variants of PSMA in prostate cancer patients. Schmittgen, T.D., Teske, S., Vessella, R.L., True, L.D., Zakrajsek, B.A. Int. J. Cancer (2003) [Pubmed]
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