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Gene Review:

Mcg1 - mitotic control gene 1

Mus musculus

This record was discontinued.

Simnett, J.D. et al., FitzHarris, G. et al., Taylor, E.M. et al., Lim, J. et al., Hernando, E. et al.

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Disease relevance of Mcg1

An increase in expression of HMC, its novel product likely to belong to a structurally distinct family of mitotic-control proteins, may be associated with malignant phenotypes of some colorectal cancers [1].

High impact information on Mcg1

The cell cycle dependent effects on ER structure and inositol 1,4,5-trisphosphate-induced Ca(2+) release have implications for understanding meiotic and mitotic control of ER structure and inheritance, and of the mechanisms regulating mitotic Ca(2+) signaling [2].
The structural maintenance of chromosomes (SMC) protein encoded by the fission yeast rad18 gene is involved in several DNA repair processes and has an essential function in DNA replication and mitotic control [3].
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control [4].
The results do not support the view that the rate of cell division is regulated by systemically-circulating mitotic control factors and it is proposed that changes in the cell division rate, both in the reparative and in the compensatory types of response, are determined by local alterations in the concentration of regulatory metabolites [5].

References

Isolation of murine and human homologues of the fission-yeast dis3+ gene encoding a mitotic-control protein and its overexpression in cancer cells with progressive phenotype. Lim, J., Kuroki, T., Ozaki, K., Kohsaki, H., Yamori, T., Tsuruo, T., Nakamori, S., Imaoka, S., Endo, M., Nakamura, Y. Cancer Res. (1997) [Pubmed]
Cell cycle-dependent regulation of structure of endoplasmic reticulum and inositol 1,4,5-trisphosphate-induced Ca2+ release in mouse oocytes and embryos. FitzHarris, G., Marangos, P., Carroll, J. Mol. Biol. Cell (2003) [Pubmed]
Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex. Taylor, E.M., Moghraby, J.S., Lees, J.H., Smit, B., Moens, P.B., Lehmann, A.R. Mol. Biol. Cell (2001) [Pubmed]
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Hernando, E., Nahlé, Z., Juan, G., Diaz-Rodriguez, E., Alaminos, M., Hemann, M., Michel, L., Mittal, V., Gerald, W., Benezra, R., Lowe, S.W., Cordon-Cardo, C. Nature (2004) [Pubmed]
Cell division and tissue repair following localized damage to the mammalian lung. Simnett, J.D., Fisher, J.M. J. Morphol. (1976) [Pubmed]

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