Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Emi1 - proviral insertion Emi 1

Mus musculus

Synonyms: Emi-1

Marangos, P. et al., Lee, H. et al., Guardavaccaro, D. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Emi1

Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APCCdh1 [1].
Finally, we show that Emi1-dependent effects on meiosis I require the presence of Cdh1 [1].
Moreover, multipolar spindles and misaligned chromosomes were frequently observed in Emi1 mutant cells, possibly due to premature APC activation [2].
Here we show, by analyzing Emi1-deficient embryos, that Emi1 is essential for precise mitotic progression during early embryogenesis [2].
Indeed, we demonstrate that Emi1 is a bona fide substrate of beta-Trcp1 [3].

Biological context of Emi1

In mouse oocytes, we find that early mitotic inhibitor 1 (Emi1), an inhibitor of the anaphase-promoting complex (APC) that is responsible for cyclin B destruction and inactivation of MPF, is present at prophase I and undergoes Skp1-Cul1-F-box/betaTrCP-mediated destruction immediately after germinal vesicle breakdown (GVBD) [1].

References

Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APCCdh1. Marangos, P., Verschuren, E.W., Chen, R., Jackson, P.K., Carroll, J. J. Cell Biol. (2007) [Pubmed]
Mouse emi1 has an essential function in mitotic progression during early embryogenesis. Lee, H., Lee, D.J., Oh, S.P., Park, H.D., Nam, H.H., Kim, J.M., Lim, D.S. Mol. Cell. Biol. (2006) [Pubmed]
Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo. Guardavaccaro, D., Kudo, Y., Boulaire, J., Barchi, M., Busino, L., Donzelli, M., Margottin-Goguet, F., Jackson, P.K., Yamasaki, L., Pagano, M. Dev. Cell (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.