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Gene Review

PPIE  -  peptidylprolyl isomerase E (cyclophilin E)

Homo sapiens

Synonyms: CYP-33, CYP33, CyP-33, Cyclophilin E, Cyclophilin-33, ...
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Disease relevance of PPIE


High impact information on PPIE

  • Histone deacetylase 1 interacts with the MLL repression domain, partially mediating its activity; binding of Cyp33 to the adjacent MLL-PHD domain potentiates this binding [3].
  • This gene, tentatively named PPIE (peptidyl-prolyl cis-trans isomerase E), has 83% amino acid identity with the central conserved region of cyclophilin A, is evolutionarily conserved by Southern blot, and exhibits differential tissue expression with highest levels found in muscle and brain [1].
  • The prognostic and functional consequences of PPIE gene amplification in SCLC can now be determined [1].
  • Here we describe a novel nuclear cyclophilin (hCyP33) from human T cells with an additional RNA-binding domain [4].
  • A key residue of the active site is changed from Ala-103-CypA to Ser-239-hCyP33, which may affect the PPIase domain/substrates interactions [2].

Anatomical context of PPIE

  • Co-amplification of PPIE was observed in seven of eleven L-myc amplified cell lines [1].

Associations of PPIE with chemical compounds

  • Superposition of the structure of the C domain of hCyP33 with the structure of CypA suggests that the C domain contains PPIase active site which binds to CsA [2].


  1. Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines. Kim, J.O., Nau, M.M., Allikian, K.A., Mäkelä, T.P., Alitalo, K., Johnson, B.E., Kelley, M.J. Oncogene (1998) [Pubmed]
  2. 1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase. Wang, T., Yun, C.H., Gu, S.Y., Chang, W.R., Liang, D.C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  3. MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein. Xia, Z.B., Anderson, M., Diaz, M.O., Zeleznik-Le, N.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. A nuclear RNA-binding cyclophilin in human T cells. Mi, H., Kops, O., Zimmermann, E., Jäschke, A., Tropschug, M. FEBS Lett. (1996) [Pubmed]
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