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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Gene Amplification

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Disease relevance of Gene Amplification


High impact information on Gene Amplification


Chemical compound and disease context of Gene Amplification


Biological context of Gene Amplification


Anatomical context of Gene Amplification


Associations of Gene Amplification with chemical compounds


Gene context of Gene Amplification


Analytical, diagnostic and therapeutic context of Gene Amplification


  1. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Almoguera, C., Shibata, D., Forrester, K., Martin, J., Arnheim, N., Perucho, M. Cell (1988) [Pubmed]
  2. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Schwab, M., Alitalo, K., Klempnauer, K.H., Varmus, H.E., Bishop, J.M., Gilbert, F., Brodeur, G., Goldstein, M., Trent, J. Nature (1983) [Pubmed]
  3. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Oliner, J.D., Pietenpol, J.A., Thiagalingam, S., Gyuris, J., Kinzler, K.W., Vogelstein, B. Nature (1993) [Pubmed]
  4. Real-world performance of HER2 testing--National Surgical Adjuvant Breast and Bowel Project experience. Paik, S., Bryant, J., Tan-Chiu, E., Romond, E., Hiller, W., Park, K., Brown, A., Yothers, G., Anderson, S., Smith, R., Wickerham, D.L., Wolmark, N. J. Natl. Cancer Inst. (2002) [Pubmed]
  5. Elevated epidermal growth factor receptor gene copy number and expression in a squamous carcinoma cell line. Merlino, G.T., Xu, Y.H., Richert, N., Clark, A.J., Ishii, S., Banks-Schlegel, S., Pastan, I. J. Clin. Invest. (1985) [Pubmed]
  6. Use of human tissue to assess the oncogenic activity of melanoma-associated mutations. Chudnovsky, Y., Adams, A.E., Robbins, P.B., Lin, Q., Khavari, P.A. Nat. Genet. (2005) [Pubmed]
  7. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Yin, Y., Tainsky, M.A., Bischoff, F.Z., Strong, L.C., Wahl, G.M. Cell (1992) [Pubmed]
  8. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Livingstone, L.R., White, A., Sprouse, J., Livanos, E., Jacks, T., Tlsty, T.D. Cell (1992) [Pubmed]
  9. Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells. Smith, K.A., Gorman, P.A., Stark, M.B., Groves, R.P., Stark, G.R. Cell (1990) [Pubmed]
  10. Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter. Sardet, C., Franchi, A., Pouysségur, J. Cell (1989) [Pubmed]
  11. Plasmid-determined tetracycline resistance in Streptococcus faecalis: evidence for gene amplification during growth in presence of tetracycline. Clewell, D.B., Yagi, Y., Bauer, B. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  12. Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer. Koivisto, P., Kononen, J., Palmberg, C., Tammela, T., Hyytinen, E., Isola, J., Trapman, J., Cleutjens, K., Noordzij, A., Visakorpi, T., Kallioniemi, O.P. Cancer Res. (1997) [Pubmed]
  13. Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials. Bell, D.W., Lynch, T.J., Haserlat, S.M., Harris, P.L., Okimoto, R.A., Brannigan, B.W., Sgroi, D.C., Muir, B., Riemenschneider, M.J., Iacona, R.B., Krebs, A.D., Johnson, D.H., Giaccone, G., Herbst, R.S., Manegold, C., Fukuoka, M., Kris, M.G., Baselga, J., Ochs, J.S., Haber, D.A. J. Clin. Oncol. (2005) [Pubmed]
  14. Amplification of adenosine deaminase gene sequences in deoxycoformycin-resistant rat hepatoma cells. Hunt, S.W., Hoffee, P.A. J. Biol. Chem. (1983) [Pubmed]
  15. Cyclin D1 gene (CCND1) mutations in endometrial cancer. Moreno-Bueno, G., Rodríguez-Perales, S., Sánchez-Estévez, C., Hardisson, D., Sarrió, D., Prat, J., Cigudosa, J.C., Matias-Guiu, X., Palacios, J. Oncogene (2003) [Pubmed]
  16. Identification of DNA sequence responsible for 5-bromodeoxyuridine-induced gene amplification. Biswas, D.K., Hartigan, J.A., Pichler, M.H. Science (1984) [Pubmed]
  17. ORC binding, gene amplification, and the nature of metazoan replication origins. Spradling, A.C. Genes Dev. (1999) [Pubmed]
  18. Dominant expression of multiple drug resistance after in vitro X-irradiation exposure in intraspecific Chinese hamster ovary hybrid cells. McClean, S., Hosking, L.K., Hill, B.T. J. Natl. Cancer Inst. (1993) [Pubmed]
  19. Genetic staging of unresectable or metastatic neuroblastoma in infants: a Pediatric Oncology Group study. Bowman, L.C., Castleberry, R.P., Cantor, A., Joshi, V., Cohn, S.L., Smith, E.I., Yu, A., Brodeur, G.M., Hayes, F.A., Look, A.T. J. Natl. Cancer Inst. (1997) [Pubmed]
  20. Amplification of a gene coding for human T-cell differentiation antigen. Kavathas, P., Herzenberg, L.A. Nature (1983) [Pubmed]
  21. Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus. Trask, B.J., Hamlin, J.L. Genes Dev. (1989) [Pubmed]
  22. ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP. Royzman, I., Austin, R.J., Bosco, G., Bell, S.P., Orr-Weaver, T.L. Genes Dev. (1999) [Pubmed]
  23. 3-Hydroxy-3-methylglutaryl-CoA reductase: a transmembrane glycoprotein of the endoplasmic reticulum with N-linked "high-mannose" oligosaccharides. Liscum, L., Cummings, R.D., Anderson, R.G., DeMartino, G.N., Goldstein, J.L., Brown, M.S. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  24. Retroviral-mediated transfer and amplification of a functional human factor VIII gene. Israel, D.I., Kaufman, R.J. Blood (1990) [Pubmed]
  25. Expression of human neurotropic polyomavirus JCV late gene product agnoprotein in human medulloblastoma. Del Valle, L., Gordon, J., Enam, S., Delbue, S., Croul, S., Abraham, S., Radhakrishnan, S., Assimakopoulou, M., Katsetos, C.D., Khalili, K. J. Natl. Cancer Inst. (2002) [Pubmed]
  26. In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition. Robinett, C.C., Straight, A., Li, G., Willhelm, C., Sudlow, G., Murray, A., Belmont, A.S. J. Cell Biol. (1996) [Pubmed]
  27. Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. Rice, G.C., Hoy, C., Schimke, R.T. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  28. Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment. Yin, D.X., Schimke, R.T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  29. Oncogene amplification in urothelial cancers with p53 gene mutation or MDM2 amplification. Habuchi, T., Kinoshita, H., Yamada, H., Kakehi, Y., Ogawa, O., Wu, W.J., Takahashi, R., Sugiyama, T., Yoshida, O. J. Natl. Cancer Inst. (1994) [Pubmed]
  30. Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma. Weinberg, D.S., Ruggeri, B., Barber, M.T., Biswas, S., Miknyocki, S., Waldman, S.A. J. Clin. Invest. (1997) [Pubmed]
  31. Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. Zhu, Y., Qi, C., Jain, S., Le Beau, M.M., Espinosa, R., Atkins, G.B., Lazar, M.A., Yeldandi, A.V., Rao, M.S., Reddy, J.K. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  32. A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma. Hughes, S.J., Glover, T.W., Zhu, X.X., Kuick, R., Thoraval, D., Orringer, M.B., Beer, D.G., Hanash, S. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  33. Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells. Raymond, M., Rose, E., Housman, D.E., Gros, P. Mol. Cell. Biol. (1990) [Pubmed]
  34. HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas. Press, M.F., Bernstein, L., Thomas, P.A., Meisner, L.F., Zhou, J.Y., Ma, Y., Hung, G., Robinson, R.A., Harris, C., El-Naggar, A., Slamon, D.J., Phillips, R.N., Ross, J.S., Wolman, S.R., Flom, K.J. J. Clin. Oncol. (1997) [Pubmed]
  35. Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme. Malden, L.T., Novak, U., Kaye, A.H., Burgess, A.W. Cancer Res. (1988) [Pubmed]
  36. ID2 expression is not associated with MYCN amplification or expression in human neuroblastomas. Wang, Q., Hii, G., Shusterman, S., Mosse, Y., Winter, C.L., Guo, C., Zhao, H., Rappaport, E., Hogarty, M.D., Maris, J.M. Cancer Res. (2003) [Pubmed]
  37. Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR. Luwor, R.B., Johns, T.G., Murone, C., Huang, H.J., Cavenee, W.K., Ritter, G., Old, L.J., Burgess, A.W., Scott, A.M. Cancer Res. (2001) [Pubmed]
  38. Fluorescent methotrexate labeling and flow cytometric analysis of cells containing low levels of dihydrofolate reductase. Gaudray, P., Trotter, J., Wahl, G.M. J. Biol. Chem. (1986) [Pubmed]
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