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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CEBPG  -  CCAAT/enhancer binding protein (C/EBP), gamma

Homo sapiens

Synonyms: C/EBP gamma, CCAAT/enhancer-binding protein gamma, GPE1BP, IG/EBP-1
 
 
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Disease relevance of CEBPG

 

High impact information on CEBPG

  • The interactions of these proteins with GPE1-BP may play key roles in G-CSF gene expression [2].
  • Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1 [3].
  • E2F1 was correlated with GSTP1 among non-BC individuals, but in contrast to CEBPG, there was no significant difference in this correlation in non-BC individuals compared to BC individuals [1].
  • CONCLUSION: We conclude that CEBPG is the transcription factor primarily responsible for regulating transcription of key antioxidant and DNA repair genes in non-BC individuals [1].
 

Biological context of CEBPG

  • Further, we conclude that the heavy smokers selected for development of BC are those who have sub-optimal regulation of antioxidant and DNA repair genes by CEBPG [1].

References

  1. CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma. Mullins, D.N., Crawford, E.L., Khuder, S.A., Hernandez, D.A., Yoon, Y., Willey, J.C. BMC Cancer (2005) [Pubmed]
  2. cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. Nishizawa, M., Nagata, S. FEBS Lett. (1992) [Pubmed]
  3. Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1. Nishizawa, M., Wakabayashi-Ito, N., Nagata, S. FEBS Lett. (1991) [Pubmed]
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