Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

GAS2L1 - growth arrest-specific 2 like 1

Homo sapiens

Synonyms: GAR22, GAS2-like protein 1, GAS2-related protein on chromosome 22, Growth arrest-specific protein 2-like 1

Goriounov, D. et al., Zucman-Rossi, J. et al.

Zucman-Rossi, Legoix, Thomas,

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High impact information on GAS2L1

The beta isoforms of hGAR17 and hGAR22 appear to be able to crosslink microtubules and microfilaments in transfected cells [1].
Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules [1].
The human Gas2-related gene on chromosome 22 (hGAR22) encodes two alternatively spliced mRNA species [1].
The overall cytoskeletal binding properties of the hGAR17 and hGAR22 proteins are remarkably similar. hGAR17 mRNA expression is limited to skeletal muscle [1].
Although hGAR22 and mGAR22 mRNAs are expressed nearly ubiquitously, mGAR22 protein can only be detected in testis and brain [1].

Anatomical context of GAS2L1

One of them, GAR22, is closely related to mouse Gas2, a gene isolated as being negatively regulated by serum and growth factors and exhibiting a high expression in growth arrested mouse fibroblasts [2].

References

Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules. Goriounov, D., Leung, C.L., Liem, R.K. J. Cell. Sci. (2003) [Pubmed]
Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region. Zucman-Rossi, J., Legoix, P., Thomas, G. Genomics (1996) [Pubmed]

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