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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GAS2  -  growth arrest-specific 2

Homo sapiens

Synonyms: GAS-2, Growth arrest-specific protein 2
 
 
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High impact information on GAS2

  • We have previously shown that the product of GAS2, a gene specifically induced at growth arrest, is an inhibitor of millicalpain and that its overexpression sensitizes cells to apoptosis in a p53-dependent manner (Benetti, R., G. Del Sal, M. Monte, G. Paroni, C. Brancolini, and C. Schneider. 2001. EMBO J. 20:2702-2714) [1].
  • On the other hand, cleavages of nuclear and cytoplasmic structural proteins (e.g. the lamins and Gas2) appear to be required for or contribute to the dramatic rearrangements in cellular architecture that are necessary for the completion of the cell death process [2].
  • Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules [3].
  • cDNA characterization and chromosome mapping of the human GAS2 gene [4].
  • Fluorescence in situ hybridization analysis and radiation hybrid mapping localized the GAS2 gene on human chromosome 11p14.3-p15.2, in a region homologous to the gas2 region on mouse chromosome 7 [4].
 

Biological context of GAS2

  • We defined a second PRL-responsive region spanning -254 to -180 that contains a second GAS site (GAS2) and an Oct-1 binding site [5].
 

Other interactions of GAS2

  • Although mutational analysis indicated independence from GAS2, proximal promoter activity remained Stat5-dependent, suggesting alternative mechanisms [5].

References

  1. Calpain is required for macroautophagy in mammalian cells. Demarchi, F., Bertoli, C., Copetti, T., Tanida, I., Brancolini, C., Eskelinen, E.L., Schneider, C. J. Cell Biol. (2006) [Pubmed]
  2. Death substrates come alive. Porter, A.G., Ng, P., Jänicke, R.U. Bioessays (1997) [Pubmed]
  3. Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules. Goriounov, D., Leung, C.L., Liem, R.K. J. Cell. Sci. (2003) [Pubmed]
  4. cDNA characterization and chromosome mapping of the human GAS2 gene. Collavin, L., Buzzai, M., Saccone, S., Bernard, L., Federico, C., DellaValle, G., Brancolini, C., Schneider, C. Genomics (1998) [Pubmed]
  5. Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter. Brockman, J.L., Schuler, L.A. Mol. Cell. Endocrinol. (2005) [Pubmed]
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