The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Ril1  -  radiation-induced leukemia sensitivity 1

Mus musculus

Synonyms: Ril-1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ril1


High impact information on Ril1

  • Radiation-induced leukemia-1 (Ril-1) on chromosome 2 plays an overriding influence in susceptibility to the disease [3].
  • Furthermore, it is intriguing that Ril-1 is located in a chromosomal site rich in thymus differentiation-specific loci [3].
  • Akvr-1 has been shown to segregate independently in backcrosses with a variety of retroviral restriction loci, including Fv-1, Fv-2, Ril-1, and Ril-2 [4].
  • A cloned genomic DNA fragment derived from a retroviral site has been used to define a novel locus, Pol-5, that is tightly linked to both H-30 and Ril-1 as shown by analysis of the B6.C-H-30c congenic mouse strain [1].
  • Currently chromosomal "walking" and "hopping" techniques are being used in conjunction with an RFLP molecular probe which is adjacent to Ril-1 [2].


  1. Assignment of the Ly-6--Ril-1--Sis--H-30--Pol-5/Xmmv-72--Ins-3--Krt-1--Int-1 --Gdc-1 region to mouse chromosome 15. Meruelo, D., Rossomando, A., Scandalis, S., D'Eustachio, P., Fournier, R.E., Roop, D.R., Saxe, D., Blatt, C., Nesbitt, M.N. Immunogenetics (1987) [Pubmed]
  2. A molecular and genetic approach to understanding the mechanisms by which fractionated X-irradiation induces leukemia in mice. Meruelo, D., Rossomando, A. Leuk. Res. (1986) [Pubmed]
  3. Genetics of susceptibility for radiation-induced leukemia. Mapping of genes involved to chromosomes 1, 2, and 4, and implications for a viral etiology in the disease. Meruelo, D., Offer, M., Flieger, N. J. Exp. Med. (1981) [Pubmed]
  4. Murine retroviral restriction genes Fv-4 and Akvr-1 are alleles of a single locus. O'Brien, S.J., Berman, E.J., Estes, J.D., Gardner, M.B. J. Virol. (1983) [Pubmed]
WikiGenes - Universities