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Gene Review:

Ril1 - radiation-induced leukemia sensitivity 1

Mus musculus

Synonyms: Ril-1

Meruelo, D. et al., Meruelo, D. et al., Meruelo, D. et al., O'Brien, S.J. et al.

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Disease relevance of Ril1

Previous work has demonstrated linkage between Ly-6, H-30, and a locus, Ril-1, that affects susceptibility to radiation-induced leukemia [1].
In addition a cDNA library has been prepared from a radiation-induced thymoma and subtraction hybridization analysis is being used in the search for Ril-1 [2].

High impact information on Ril1

Radiation-induced leukemia-1 (Ril-1) on chromosome 2 plays an overriding influence in susceptibility to the disease [3].
Furthermore, it is intriguing that Ril-1 is located in a chromosomal site rich in thymus differentiation-specific loci [3].
Akvr-1 has been shown to segregate independently in backcrosses with a variety of retroviral restriction loci, including Fv-1, Fv-2, Ril-1, and Ril-2 [4].
A cloned genomic DNA fragment derived from a retroviral site has been used to define a novel locus, Pol-5, that is tightly linked to both H-30 and Ril-1 as shown by analysis of the B6.C-H-30c congenic mouse strain [1].
Currently chromosomal "walking" and "hopping" techniques are being used in conjunction with an RFLP molecular probe which is adjacent to Ril-1 [2].

References

Assignment of the Ly-6--Ril-1--Sis--H-30--Pol-5/Xmmv-72--Ins-3--Krt-1--Int-1 --Gdc-1 region to mouse chromosome 15. Meruelo, D., Rossomando, A., Scandalis, S., D'Eustachio, P., Fournier, R.E., Roop, D.R., Saxe, D., Blatt, C., Nesbitt, M.N. Immunogenetics (1987) [Pubmed]
A molecular and genetic approach to understanding the mechanisms by which fractionated X-irradiation induces leukemia in mice. Meruelo, D., Rossomando, A. Leuk. Res. (1986) [Pubmed]
Genetics of susceptibility for radiation-induced leukemia. Mapping of genes involved to chromosomes 1, 2, and 4, and implications for a viral etiology in the disease. Meruelo, D., Offer, M., Flieger, N. J. Exp. Med. (1981) [Pubmed]
Murine retroviral restriction genes Fv-4 and Akvr-1 are alleles of a single locus. O'Brien, S.J., Berman, E.J., Estes, J.D., Gardner, M.B. J. Virol. (1983) [Pubmed]

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