Disease relevance of Bai1

• The BAI1 expression decreased on the ischemic side after 24 h but BAP4 was not changed after the time-course of ischemia [1].
• Because BAI1 possessed thrombospondin-type 1 repeats in its extracellular region, changes of BAI1 expression were examined in the focal cerebral ischemia model [1].
• In this study, we investigated the in vivo antiangiogenic and antitumor effects of brain-specific angiogenesis inhibitor 1 (BAI1) using human glioblastoma cell lines [2].

High impact information on Bai1

• In situ hybridization analyses of the brain showed the same localization of BAI1 as BAP4, such as most neurons of cerebral cortex, hippocampus, and V, VI, VII, VIII, and XII nuclei [1].

Analytical, diagnostic and therapeutic context of Bai1

• Northern and Western blot analyses demonstrated a unique pattern of BAI1 expression in the brain [1].
• The ability of BAP4 to interact with BAI1 was confirmed by pulling-down BAI1 with GST-BAP4 protein and immunoprecipitation study using brain lysate [1].

References