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Gene Review

BAI1  -  brain-specific angiogenesis inhibitor 1

Homo sapiens

Synonyms: Brain-specific angiogenesis inhibitor 1
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Disease relevance of BAI1

  • We hypothesized that the BAI family might have anti-tumoral properties and studied the expression of BAI1 protein in normal human brain and in glioblastoma multiforme [1].
  • BAI1 expression was significantly reduced in colorectal cancers as compared to the extraneoplastic tissues (X(2) test, p=0.041) [2].
  • BAI1 expression was inversely correlated with vascular invasion and metastasis (Fisher's exact test, p 0.045) [2].
  • Taken together, these data strongly indicate that BAI1 may be an excellent gene therapy candidate for the treatment of brain tumors, especially human glioblastomas [3].
  • It is suggested that the extent of BAI1 and TIMP-2 expression in the gastric mucosa may be an important prognostic factor for predicting survival in gastric cancer [4].

High impact information on BAI1


Biological context of BAI1


Anatomical context of BAI1


Associations of BAI1 with chemical compounds

  • Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1 [13].

Physical interactions of BAI1


Regulatory relationships of BAI1

  • However, in spite of similar tissue specificity among the three BAI genes, only BAI1 is transcriptionally regulated by p53 [14].

Other interactions of BAI1

  • Using a two-hybrid system, we isolated a cDNA that encodes a protein, named BAP1 (BAI1-associated protein), which interacts with the cytoplasmic region of BAI1 [8].
  • Glioblastomas with no BAI-1 and high VEGF mRNA expression are more often associated with poor clinical outcome [15].

Analytical, diagnostic and therapeutic context of BAI1


  1. Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. Kaur, B., Brat, D.J., Calkins, C.C., Van Meir, E.G. Am. J. Pathol. (2003) [Pubmed]
  2. Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer. Fukushima, Y., Oshika, Y., Tsuchida, T., Tokunaga, T., Hatanaka, H., Kijima, H., Yamazaki, H., Ueyama, Y., Tamaoki, N., Nakamura, M. Int. J. Oncol. (1998) [Pubmed]
  3. Antiangiogenic activity of BAI1 in vivo: implications for gene therapy of human glioblastomas. Kang, X., Xiao, X., Harata, M., Bai, Y., Nakazaki, Y., Soda, Y., Kurita, R., Tanaka, T., Komine, F., Izawa, K., Kunisaki, R., Setoyama, M., Nishimori, H., Natsume, A., Sunamura, M., Lozonshi, L., Saitoh, I., Tokino, T., Asano, S., Nakamura, Y., Tani, K. Cancer Gene Ther. (2006) [Pubmed]
  4. Comparative study of angiostatic and anti-invasive gene expressions as prognostic factors in gastric cancer. Lee, J.H., Koh, J.T., Shin, B.A., Ahn, K.Y., Roh, J.H., Kim, Y.J., Kim, K.K. Int. J. Oncol. (2001) [Pubmed]
  5. A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis. Nishimori, H., Shiratsuchi, T., Urano, T., Kimura, Y., Kiyono, K., Tatsumi, K., Yoshida, S., Ono, M., Kuwano, M., Nakamura, Y., Tokino, T. Oncogene (1997) [Pubmed]
  6. Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin. Koh, J.T., Kook, H., Kee, H.J., Seo, Y.W., Jeong, B.C., Lee, J.H., Kim, M.Y., Yoon, K.C., Jung, S., Kim, K.K. Exp. Cell Res. (2004) [Pubmed]
  7. Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. Kee, H.J., Koh, J.T., Kim, M.Y., Ahn, K.Y., Kim, J.K., Bae, C.S., Park, S.S., Kim, K.K. J. Cereb. Blood Flow Metab. (2002) [Pubmed]
  8. Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. Shiratsuchi, T., Futamura, M., Oda, K., Nishimori, H., Nakamura, Y., Tokino, T. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  9. Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells. Mori, K., Kanemura, Y., Fujikawa, H., Nakano, A., Ikemoto, H., Ozaki, I., Matsumoto, T., Tamura, K., Yokota, M., Arita, N. Neurosci. Res. (2002) [Pubmed]
  10. Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. Duda, D.G., Sunamura, M., Lozonschi, L., Yokoyama, T., Yatsuoka, T., Motoi, F., Horii, A., Tani, K., Asano, S., Nakamura, Y., Matsuno, S. Br. J. Cancer (2002) [Pubmed]
  11. Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. Oda, K., Shiratsuchi, T., Nishimori, H., Inazawa, J., Yoshikawa, H., Taketani, Y., Nakamura, Y., Tokino, T. Cytogenet. Cell Genet. (1999) [Pubmed]
  12. Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma. Kee, H.J., Ahn, K.Y., Choi, K.C., Won Song, J., Heo, T., Jung, S., Kim, J.K., Bae, C.S., Kim, K.K. FEBS Lett. (2004) [Pubmed]
  13. Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1. Shiratsuchi, T., Oda, K., Nishimori, H., Suzuki, M., Takahashi, E., Tokino, T., Nakamura, Y. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  14. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). Shiratsuchi, T., Nishimori, H., Ichise, H., Nakamura, Y., Tokino, T. Cytogenet. Cell Genet. (1997) [Pubmed]
  15. Expression of VEGF and brain specific angiogenesis inhibitor-1 in glioblastoma: prognostic significance. Nam, D.H., Park, K., Suh, Y.L., Kim, J.H. Oncol. Rep. (2004) [Pubmed]
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