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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Table of contents

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Gene Review: 

CFHR3  -  complement factor H-related 3

Homo sapiens

Synonyms: CFHL3, Complement factor H-related protein 3, DOWN16, FHR-3, FHR3, ...
 
 
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Disease relevance of CFHR3

 

High impact information on CFHR3

  • A protein consisting of SCRs 19 and 20 did not bind heparin, whereas SCRs 18-20 did, indicating that, although SCR 20 contains a heparin binding site, at least two nonspecific adjacent SCRs are required. fH-related protein-3 (FHR-3) possesses an SCR homologous to SCR 7 of fH and bound heparin, whereas FHR-4, which lacks such an SCR, did not [2].
  • The DOWN16 clone is 1269 base pairs in size and hybridized to a mRNA of 1.4 kilobases [3].
  • In experiments studying which short consensus repeat (SCR) domains are part of the cell membrane proteins we found that antibodies raised against SCRs 1-4, 19-20 and FHR-3 bound to neutrophils but not to B cells [4].
 

Biological context of CFHR3

 

Other interactions of CFHR3

  • The interaction of FHR-3, but not of FHR4, with opsonised pneumococci was inhibited by heparin [6].

References

  1. Corrigendum: A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. Hughes, A.E., Orr, N., Esfandiary, H., Diaz-Torres, M., Goodship, T., Chakravarthy, U. Nat. Genet. (2007) [Pubmed]
  2. Identification of the second heparin-binding domain in human complement factor H. Blackmore, T.K., Hellwage, J., Sadlon, T.A., Higgs, N., Zipfel, P.F., Ward, H.M., Gordon, D.L. J. Immunol. (1998) [Pubmed]
  3. A novel short consensus repeat-containing molecule is related to human complement factor H. Skerka, C., Kühn, S., Günther, K., Lingelbach, K., Zipfel, P.F. J. Biol. Chem. (1993) [Pubmed]
  4. Characterization of factor H-related cell membrane molecules expressed by human B lymphocytes and neutrophil granulocytes. Józsi, M., Kapus, A., Kerekes, K., Kármán, J., Bajtay, Z., Zipfel, P.F., Erdei, A. Immunol. Lett. (2001) [Pubmed]
  5. A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. Hughes, A.E., Orr, N., Esfandiary, H., Diaz-Torres, M., Goodship, T., Chakravarthy, U. Nat. Genet. (2006) [Pubmed]
  6. Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin. Hellwage, J., Jokiranta, T.S., Koistinen, V., Vaarala, O., Meri, S., Zipfel, P.F. FEBS Lett. (1999) [Pubmed]
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