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Gene Review

CFHR1  -  complement factor H-related 1

Homo sapiens

Synonyms: CFHL, CFHL1, CFHL1P, CFHR1P, Complement factor H-related protein 1, ...
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Disease relevance of CFHR1


High impact information on CFHR1


Biological context of CFHR1


Anatomical context of CFHR1

  • The expression of the T cell receptor (Ti)-alpha and -beta subunits in human thymocytes was studied with the use of two rabbit antisera directed at constant regions of human Ti-alpha- and Ti-beta-chains (H36 and H38, respectively) [13].
  • Stimulation of HFL-1 cells with IFN-gamma up-regulated adhesion of eosinophils, but not neutrophils, to HFL-1 cells [7].
  • Collagen degradation in two other lung cell lines, Wl-38 and lMR-90, did not differ from the level in HFL-1 [14].
  • A novel, complement factor H-related regulatory protein expressed on the surface of human B cell lines [15].
  • Coculture of nonleukemic stromal cells and AML blasts separated by a semipermeable membrane decreased proliferation of the fibroblast line HFL1, and the inhibition was maintained when HFL1 and AML cells were cultured in direct contact [16].

Associations of CFHR1 with chemical compounds


Regulatory relationships of CFHR1


Other interactions of CFHR1


Analytical, diagnostic and therapeutic context of CFHR1


  1. Corrigendum: A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. Hughes, A.E., Orr, N., Esfandiary, H., Diaz-Torres, M., Goodship, T., Chakravarthy, U. Nat. Genet. (2007) [Pubmed]
  2. A proteomic approach to mimic fibrosis disease evolvement by an in vitro cell line. Malmström, J., Westergren-Thorsson, G., Marko-Varga, G. Electrophoresis (2001) [Pubmed]
  3. The use of monoclonal antibodies against primary myeloid granules in normal and leukemic cells. Elghetany, M.T., Sullivan, A.K., Kurec, A.S., MacCallum, J.M., Bloomfield, C.D., Sobol, R.E., Davey, F.R. Am. J. Clin. Pathol. (1992) [Pubmed]
  4. Complement-dependent cytotoxic antibodies to human T lymphotropic virus type I (HTLV-I)-infected cells in the sera of HTLV-I-infected individuals. Plotnicky-Gilquin, H., Afani, A., Vernant, J.C., Desgranges, C. Clin. Exp. Immunol. (1996) [Pubmed]
  5. Quantitative detection of human complement factor H-related protein in transitional cell carcinoma of the urinary bladder. Heicappell, R., Wettig, I.C., Schostak, M., Müller, M., Steiner, U., Sauter, T., Miller, K. Eur. Urol. (1999) [Pubmed]
  6. SGCE missense mutations that cause myoclonus-dystonia syndrome impair {varepsilon}-sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA. Esapa, C.T., Waite, A., Locke, M., Benson, M.A., Kraus, M., McIlhinney, R.A., Sillitoe, R.V., Beesley, P.W., Blake, D.J. Hum. Mol. Genet. (2007) [Pubmed]
  7. Selective eosinophil adhesion to fibroblast via IFN-gamma-induced galectin-9. Asakura, H., Kashio, Y., Nakamura, K., Seki, M., Dai, S., Shirato, Y., Abedin, M.J., Yoshida, N., Nishi, N., Imaizumi, T., Saita, N., Toyama, Y., Takashima, H., Nakamura, T., Ohkawa, M., Hirashima, M. J. Immunol. (2002) [Pubmed]
  8. The human factor H-related protein 4 (FHR-4). A novel short consensus repeat-containing protein is associated with human triglyceride-rich lipoproteins. Skerka, C., Hellwage, J., Weber, W., Tilkorn, A., Buck, F., Marti, T., Kampen, E., Beisiegel, U., Zipfel, P.F. J. Biol. Chem. (1997) [Pubmed]
  9. Molecular cloning of a human serum protein structurally related to complement factor H. Skerka, C., Horstmann, R.D., Zipfel, P.F. J. Biol. Chem. (1991) [Pubmed]
  10. Atypical haemolytic uraemic syndrome associated with a hybrid complement gene. Venables, J.P., Strain, L., Routledge, D., Bourn, D., Powell, H.M., Warwicker, P., Diaz-Torres, M.L., Sampson, A., Mead, P., Webb, M., Pirson, Y., Jackson, M.S., Hughes, A., Wood, K.M., Goodship, J.A., Goodship, T.H. PLoS Med. (2006) [Pubmed]
  11. Procollagen production and procollagen messenger RNA levels and activity in human lung fibroblasts during periods of rapid and stationary growth. Tolstoshev, P., Berg, R.A., Rennard, S.I., Bradley, K.H., Trapnell, B.C., Crystal, R.G. J. Biol. Chem. (1981) [Pubmed]
  12. Control of collagen production by human diploid lung fibroblasts. Breul, S.D., Bradley, K.H., Hance, A.J., Schafer, M.P., Berg, R.A., Crystal, R.G. J. Biol. Chem. (1980) [Pubmed]
  13. Expression of T cell receptor-alpha and -beta subunits in human thymocytes. An immunocytologic study. Maggiano, N., Larocca, L.M., Piantelli, M., Acuto, O., Musiani, P. J. Immunol. (1987) [Pubmed]
  14. Collagen degradation in human lung fibroblasts: extent of degradation, role of lysosomal proteases, and evaluation of an alternate hypothesis. Bienkowski, R.S. J. Cell. Physiol. (1984) [Pubmed]
  15. A novel, complement factor H-related regulatory protein expressed on the surface of human B cell lines. Erdei, A., Julen, N., Marschang, P., Feifel, E., Kerekes, K., Dierich, M.P. Eur. J. Immunol. (1994) [Pubmed]
  16. In vitro effects of native human acute myelogenous leukemia blasts on fibroblasts and osteoblasts. Glenjen, N., Ersvaer, E., Ryningen, A., Bruserud, Ø. Int. J. Cancer (2004) [Pubmed]
  17. Factor H family proteins: on complement, microbes and human diseases. Zipfel, P.F., Skerka, C., Hellwage, J., Jokiranta, S.T., Meri, S., Brade, V., Kraiczy, P., Noris, M., Remuzzi, G. Biochem. Soc. Trans. (2002) [Pubmed]
  18. Albumin-mediated regulation of cellular glutathione and nuclear factor kappa B activation. Cantin, A.M., Paquette, B., Richter, M., Larivée, P. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  19. Erythromycin modulates eosinophil chemotactic cytokine production by human lung fibroblasts in vitro. Sato, E., Nelson, D.K., Koyama, S., Hoyt, J.C., Robbins, R.A. Antimicrob. Agents Chemother. (2001) [Pubmed]
  20. Histamine and serotonin stimulate eotaxin production by a human lung fibroblast cell line. Sato, E., Haniuda, M., Numanami, H., Ushiyama, T., Tsukadaira, A., Takashi, S., Okubo, Y., Koyama, S. Int. Arch. Allergy Immunol. (2002) [Pubmed]
  21. The factor H protein family. Zipfel, P.F., Jokiranta, T.S., Hellwage, J., Koistinen, V., Meri, S. Immunopharmacology (1999) [Pubmed]
  22. C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts. Utsugi, M., Dobashi, K., Ishizuka, T., Masubuchi, K., Shimizu, Y., Nakazawa, T., Mori, M. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  23. Differential Regulation of Eotaxin-1/CCL11 and Eotaxin-3/CCL26 Production by the TNF-alpha and IL-4 Stimulated Human Lung Fibroblast. Rokudai, A., Terui, Y., Kuniyoshi, R., Mishima, Y., Mishima, Y., Aizu-Yokota, E., Sonoda, Y., Kasahara, T., Hatake, K. Biol. Pharm. Bull. (2006) [Pubmed]
  24. Complement factor H as a marker for detection of bladder cancer. Cheng, Z.Z., Corey, M.J., Pärepalo, M., Majno, S., Hellwage, J., Zipfel, P.F., Kinders, R.J., Raitanen, M., Meri, S., Jokiranta, T.S. Clin. Chem. (2005) [Pubmed]
  25. De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome. Heinen, S., Sanchez-Corral, P., Jackson, M.S., Strain, L., Goodship, J.A., Kemp, E.J., Skerka, C., Jokiranta, T.S., Meyers, K., Wagner, E., Robitaille, P., Esparza-Gordillo, J., Rodriguez de Cordoba, S., Zipfel, P.F., Goodship, T.H. Hum. Mutat. (2006) [Pubmed]
  26. Extracellular glutathione suppresses human lung fibroblast proliferation. Cantin, A.M., Larivée, P., Bégin, R.O. Am. J. Respir. Cell Mol. Biol. (1990) [Pubmed]
  27. Effect of intravesical instillations on the human complement factor H related protein (BTA stat) Test. Droller, M.J. J. Urol. (2002) [Pubmed]
  28. Continuous psoas compartment blocks after major orthopedic surgery in children: a prospective computed tomographic scan and clinical studies. Dadure, C., Raux, O., Gaudard, P., Sagintaah, M., Troncin, R., Rochette, A., Capdevila, X. Anesth. Analg. (2004) [Pubmed]
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