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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SUGT1  -  SGT1, suppressor of G2 allele of SKP1 (S....

Homo sapiens

Synonyms: Protein 40-6-3, SGT1, Sgt1, Suppressor of G2 allele of SKP1 homolog
 
 
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High impact information on SUGT1

  • Biochemical and genetic results suggest that HSP90, through its interaction with SGT1 (SUGT1), is required for kinetochore assembly [1].
  • The presence of Sgt1 in post-mitotic neurons indicates the involvement of this protein in a process different from that required for activity of the kinetochore [2].
  • In normal brain we observed Sgt1-immunostaining in Purkinje cells of the cerebellum, in granule cells of the dentate gyrus of the hippocampus and in multiple neurons of the cortex [2].
  • Expressed sequence tags (ESTs) were identified in the available database by searching for protein homology to the Sgt1 (SOLtu:Sgt1) steriodalalkaloid galactosyltransferase [3].
  • The Sgt2 gene was identified by deduced protein sequence homology to the previously identified Sgt1 gene [4].
 

Analytical, diagnostic and therapeutic context of SUGT1

References

  1. 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation. Niikura, Y., Ohta, S., Vandenbeldt, K.J., Abdulle, R., McEwen, B.F., Kitagawa, K. Oncogene (2006) [Pubmed]
  2. Density of Sgt1-immunopositive neurons is decreased in the cerebral cortex of Alzheimer's disease brain. Spiechowicz, M., Bernstein, H.G., Dobrowolny, H., Leśniak, W., Mawrin, C., Bogerts, B., Kuźnicki, J., Filipek, A. Neurochem. Int. (2006) [Pubmed]
  3. Potato glycosterol rhamnosyltransferase, the terminal step in triose side-chain biosynthesis. McCue, K.F., Allen, P.V., Shepherd, L.V., Blake, A., Malendia Maccree, M., Rockhold, D.R., Novy, R.G., Stewart, D., Davies, H.V., Belknap, W.R. Phytochemistry (2007) [Pubmed]
  4. The primary in vivo steroidal alkaloid glucosyltransferase from potato. McCue, K.F., Allen, P.V., Shepherd, L.V., Blake, A., Whitworth, J., Maccree, M.M., Rockhold, D.R., Stewart, D., Davies, H.V., Belknap, W.R. Phytochemistry (2006) [Pubmed]
  5. Involvement of HTLV-I Tax and CREB in aneuploidy: a bioinformatics approach. de la Fuente, C., Gupta, M.V., Klase, Z., Strouss, K., Cahan, P., McCaffery, T., Galante, A., Soteropoulos, P., Pumfery, A., Fujii, M., Kashanchi, F. Retrovirology (2006) [Pubmed]
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