Gene Review:
CREB1 - cAMP responsive element binding protein 1
Homo sapiens
Synonyms:
CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1
Marazita,
Huang,
Labow,
Maher,
Zubenko,
Hughes,
Pandey,
Zubenko,
Maher,
Zubenko,
Kaplan,
Hughes,
Feng,
Feng,
Stevenson,
Wu,
Handschin,
Stiffler,
Brechbiel,
Marazita,
Spiegelman,
Gullicksen,
D. Wu,
H.E. Zhau,
W.C. Huang,
S. Iqbal,
F.K. Habib,
O. Sartor,
L. Cvitanovic,
F.F. Marshall,
Z. Xu,
L. W. K. Chung,
Bare,
Stiffler,
Zubenko,
- Protein domains involved in both in vivo and in vitro interactions between human T-cell leukemia virus type I tax and CREB. Yin, M.J., Paulssen, E.J., Seeler, J.S., Gaynor, R.B. J. Virol. (1995)
- Transcriptional coactivator cAMP response element binding protein mediates induction of the human proliferating cell nuclear antigen promoter by the adenovirus E1A oncoprotein. Lee, B.H., Mathews, M.B. Proc. Natl. Acad. Sci. U.S.A. (1997)
- CREB and its associated proteins act as survival factors for human melanoma cells. Jean, D., Harbison, M., McConkey, D.J., Ronai, Z., Bar-Eli, M. J. Biol. Chem. (1998)
- Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-alpha. Taylor, C.T., Fueki, N., Agah, A., Hershberg, R.M., Colgan, S.P. J. Biol. Chem. (1999)
- Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK. Nishihara, H., Hwang, M., Kizaka-Kondoh, S., Eckmann, L., Insel, P.A. J. Biol. Chem. (2004)
- Molecular characterization of the Tax-containing HTLV-1 enhancer complex reveals a prominent role for CREB phosphorylation in Tax transactivation. Kim, Y.M., Ramírez, J.A., Mick, J.E., Giebler, H.A., Yan, J.P., Nyborg, J.K. J. Biol. Chem. (2007)
- Sequence variations in CREB1 cosegregate with depressive disorders in women. Zubenko, G.S., Hughes, H.B., Stiffler, J.S., Brechbiel, A., Zubenko, W.N., Maher, B.S., Marazita, M.L. Mol. Psychiatry (2003)
- The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction. Pandey, S.C. Pharmacol. Ther. (2004)
- CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects. Barco, A., Pittenger, C., Kandel, E.R. Expert Opin. Ther. Targets (2003)
- Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression. Zubenko, G.S., Maher, B., Hughes, H.B., Zubenko, W.N., Stiffler, J.S., Kaplan, B.B., Marazita, M.L. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2003)
- CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Shaywitz, A.J., Greenberg, M.E. Annu. Rev. Biochem. (1999)
- A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia. Horvath, A., Boikos, S., Giatzakis, C., Robinson-White, A., Groussin, L., Griffin, K.J., Stein, E., Levine, E., Delimpasi, G., Hsiao, H.P., Keil, M., Heyerdahl, S., Matyakhina, L., Libè, R., Fratticci, A., Kirschner, L.S., Cramer, K., Gaillard, R.C., Bertagna, X., Carney, J.A., Bertherat, J., Bossis, I., Stratakis, C.A. Nat. Genet. (2006)
- The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Screaton, R.A., Conkright, M.D., Katoh, Y., Best, J.L., Canettieri, G., Jeffries, S., Guzman, E., Niessen, S., Yates, J.R., Takemori, H., Okamoto, M., Montminy, M. Cell (2004)
- Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF. Bébien, M., Salinas, S., Becamel, C., Richard, V., Linares, L., Hipskind, R.A. Oncogene (2003)
- Nitric oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response element-binding protein (CREB) activation. Ciani, E., Guidi, S., Della Valle, G., Perini, G., Bartesaghi, R., Contestabile, A. J. Biol. Chem. (2002)
- The 3',5'-cyclic adenosine monophosphate response element binding protein (CREB) is functionally reduced in human toxic thyroid adenomas. Brunetti, A., Chiefari, E., Filetti, S., Russo, D. Endocrinology (2000)
- Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Al-Wadei, H.A., Takahashi, T., Schuller, H.M. Int. J. Cancer (2006)
- Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells. Pradeep, C.R., Kuttan, G. Int. Immunopharmacol. (2004)
- Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Iourgenko, V., Zhang, W., Mickanin, C., Daly, I., Jiang, C., Hexham, J.M., Orth, A.P., Miraglia, L., Meltzer, J., Garza, D., Chirn, G.W., McWhinnie, E., Cohen, D., Skelton, J., Terry, R., Yu, Y., Bodian, D., Buxton, F.P., Zhu, J., Song, C., Labow, M.A. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves {gamma}-globin activation by CREB1 and ATF-2. Sangerman, J., Lee, M.S., Yao, X., Oteng, E., Hsiao, C.H., Li, W., Zein, S., Ofori-Acquah, S.F., Pace, B.S. Blood (2006)
- cAMP induced modifications of HOX D gene expression in prostate cells allow the identification of a chromosomal area involved in vivo with neuroendocrine differentiation of human advanced prostate cancers. Cantile, M., Kisslinger, A., Cindolo, L., Schiavo, G., D'Antò, V., Franco, R., Altieri, V., Gallo, A., Villacci, A., Tramontano, D., Cillo, C. J. Cell. Physiol. (2005)
- De Novo synthesis of CREB in a presynaptic neuron is required for synaptic enhancement involved in memory consolidation. Wagatsuma, A., Azami, S., Sakura, M., Hatakeyama, D., Aonuma, H., Ito, E. J. Neurosci. Res. (2006)
- The activity of the Epstein-Barr virus BamHI W promoter in B cells is dependent on the binding of CREB/ATF factors. Kirby, H., Rickinson, A., Bell, A. J. Gen. Virol. (2000)
- CREB in the pond snail Lymnaea stagnalis: cloning, gene expression, and function in identifiable neurons of the central nervous system. Sadamoto, H., Sato, H., Kobayashi, S., Murakami, J., Aonuma, H., Ando, H., Fujito, Y., Hamano, K., Awaji, M., Lukowiak, K., Urano, A., Ito, E. J. Neurobiol. (2004)
- Assignment of the human gene for CREB1 to chromosome 2q32.3-q34. Taylor, A.K., Klisak, I., Mohandas, T., Sparkes, R.S., Li, C., Gaynor, R., Lusis, A.J. Genomics (1990)
- Identification and characterization of a cAMP-responsive element in the region upstream from promoter 1.3 of the human aromatase gene. Zhou, D., Chen, S. Arch. Biochem. Biophys. (1999)
- Effects of vitamin E and prostaglandin E2 on expression of CREB1 and CREB2 proteins by human T lymphocytes. Valenti, A., Venza, I., Venza, M., Fimiani, V., Teti, D. Physiological research / Academia Scientiarum Bohemoslovaca. (2000)
- Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Xing, J., Kornhauser, J.M., Xia, Z., Thiele, E.A., Greenberg, M.E. Mol. Cell. Biol. (1998)
- Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival. Scheid, M.P., Foltz, I.N., Young, P.R., Schrader, J.W., Duronio, V. Blood (1999)
- Oct-1 potentiates CREB-driven cyclin D1 promoter activation via a phospho-CREB- and CREB binding protein-independent mechanism. Boulon, S., Dantonel, J.C., Binet, V., Vié, A., Blanchard, J.M., Hipskind, R.A., Philips, A. Mol. Cell. Biol. (2002)
- Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family. Sawada, J., Simizu, N., Suzuki, F., Sawa, C., Goto, M., Hasegawa, M., Imai, T., Watanabe, H., Handa, H. J. Biol. Chem. (1999)
- Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells. Wang, J.M., Tseng, J.T., Chang, W.C. Mol. Biol. Cell (2005)
- Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF-1/CREB2. Butscher, W.G., Powers, C., Olive, M., Vinson, C., Gardner, K. J. Biol. Chem. (1998)
- CREB/PKA sensitive signalling pathways activate and maintain expression levels of the hepatitis B virus pre-S2/S promoter. Tacke, F., Liedtke, C., Bocklage, S., Manns, M.P., Trautwein, C. Gut (2005)
- Induction of MUC8 gene expression by interleukin-1 beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells. Song, K.S., Seong, J.K., Chung, K.C., Lee, W.J., Kim, C.H., Cho, K.N., Kang, C.D., Koo, J.S., Yoon, J.H. J. Biol. Chem. (2003)
- RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). Pierrat, B., Correia, J.S., Mary, J.L., Tomás-Zuber, M., Lesslauer, W. J. Biol. Chem. (1998)
- Potentiation of signal transduction mitogenesis and cellular proliferation upon binding of receptor-recognized forms of alpha2-macroglobulin to 1-LN prostate cancer cells. Misra, U.K., Pizzo, S.V. Cell. Signal. (2004)
- Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells. Yang, E.J., Ahn, Y.S., Chung, K.C. J. Biol. Chem. (2001)
- Vitamin D autocrine system and prostate cancer. Wang, L., Whitlatch, L.W., Flanagan, J.N., Holick, M.F., Chen, T.C. Recent Results Cancer Res. (2003)
- Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation. Tucholski, J., Johnson, G.V. J. Biol. Chem. (2003)
- HLA-G transactivation by cAMP-response element-binding protein (CREB). An alternative transactivation pathway to the conserved major histocompatibility complex (MHC) class I regulatory routes. Gobin, S.J., Biesta, P., de Steenwinkel, J.E., Datema, G., van den Elsen, P.J. J. Biol. Chem. (2002)
- Regulation of mucin gene expression by CREB via a nonclassical retinoic acid signaling pathway. Kim, S.W., Hong, J.S., Ryu, S.H., Chung, W.C., Yoon, J.H., Koo, J.S. Mol. Cell. Biol. (2007)
- cAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasis. Wu, D., Zhau, H.E., Huang, W.C., Iqbal, S., Habib, F.K., Sartor, O., Cvitanovic, L., Marshall, F.F., Xu, Z., Chung, L.W. Oncogene (2007)
- Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex. Canettieri, G., Morantte, I., Guzmán, E., Asahara, H., Herzig, S., Anderson, S.D., Yates, J.R., Montminy, M. Nat. Struct. Biol. (2003)
- Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. Ravnskjaer, K., Kester, H., Liu, Y., Zhang, X., Lee, D., Yates, J.R., Montminy, M. EMBO J. (2007)
- Identification of a novel cyclic AMP-response element (CRE-II) and the role of CREB-1 in the cAMP-induced expression of the survival motor neuron (SMN) gene. Majumder, S., Varadharaj, S., Ghoshal, K., Monani, U., Burghes, A.H., Jacob, S.T. J. Biol. Chem. (2004)
- Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1{alpha} transcription and mitochondrial biogenesis in muscle cells. Wu, Z., Huang, X., Feng, Y., Handschin, C., Feng, Y., Gullicksen, P.S., Bare, O., Labow, M., Spiegelman, B., Stevenson, S.C. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Two CGTCA motifs and a GHF1/Pit1 binding site mediate cAMP-dependent protein kinase A regulation of human growth hormone gene expression in rat anterior pituitary GC cells. Shepard, A.R., Zhang, W., Eberhardt, N.L. J. Biol. Chem. (1994)