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Gene Review

DBF4  -  DBF4 zinc finger

Homo sapiens

Synonyms: ASK, Activator of S phase kinase, CHIF, Chiffon homolog A, DBF4-type zinc finger-containing protein 1, ...
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High impact information on DBF4


Biological context of DBF4

  • Cdc7 kinase activity fluctuates during cell cycle, and this is mainly the result of oscillation of expression of the Dbf4 subunit [4].
  • Cdc7-Dbf4 kinase is conserved through evolution and regulates initiation and progression of DNA replication [3].
  • We report here the direct interaction of chromatin assembly factor 1 (CAF1), a key factor involved in histone deposition, with the replication kinase Cdc7-Dbf4 [5].

Regulatory relationships of DBF4

  • Cdc7 kinase is required for DNA replication and its kinase activity is cell cycle-regulated by its activation subunit Dbf4/ASK [6].


  1. Cdc7-Dbf4 Phosphorylates MCM Proteins via a Docking Site-Mediated Mechanism to Promote S Phase Progression. Sheu, Y.J., Stillman, B. Mol. Cell (2006) [Pubmed]
  2. Cdc7-Dbf4 and the Human S Checkpoint Response to UVC. Heffernan, T.P., Unsal-Kaçmaz, K., Heinloth, A.N., Simpson, D.A., Paules, R.S., Sancar, A., Cordeiro-Stone, M., Kaufmann, W.K. J. Biol. Chem. (2007) [Pubmed]
  3. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. Yoshizawa-Sugata, N., Ishii, A., Taniyama, C., Matsui, E., Arai, K., Masai, H. J. Biol. Chem. (2005) [Pubmed]
  4. A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase. Yamada, M., Sato, N., Taniyama, C., Ohtani, K., Arai, K., Masai, H. J. Biol. Chem. (2002) [Pubmed]
  5. The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen. Gérard, A., Koundrioukoff, S., Ramillon, V., Sergère, J.C., Mailand, N., Quivy, J.P., Almouzni, G. EMBO Rep. (2006) [Pubmed]
  6. Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7-ASK kinase complex. Sato, N., Sato, M., Nakayama, M., Saitoh, R., Arai, K., Masai, H. Genes Cells (2003) [Pubmed]
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