Gene Review:
CHEK1 - checkpoint kinase 1
Homo sapiens
Synonyms:
CHK1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1, Serine/threonine-protein kinase Chk1
- 7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines. Xiao, H.H., Makeyev, Y., Butler, J., Vikram, B., Franklin, W.A. Radiat. Res. (2002)
- Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. Maude, S.L., Enders, G.H. Cancer Res. (2005)
- Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability. Menoyo, A., Alazzouzi, H., Espín, E., Armengol, M., Yamamoto, H., Schwartz, S. Cancer Res. (2001)
- Mutational analysis of Chk1, Chk2, Apaf1 and Rb1 in human malignant melanoma cell lines. Papp, T., Niemetz, A., Dosdahl, N., Kumar, K., Schiffmann, D. Oncol. Rep. (2007)
- Influence of chk1 and plk1 silencing on radiation- or cisplatin-induced cytotoxicity in human malignant cells. Gao, Q., Huang, X., Tang, D., Cao, Y., Chen, G., Lu, Y., Zhuang, L., Wang, S., Xu, G., Zhou, J., Ma, D. Apoptosis (2006)
- The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas. Verlinden, L., Vanden Bempt, I., Eelen, G., Drijkoningen, M., Verlinden, I., Marchal, K., De Wolf-Peeters, C., Christiaens, M.R., Michiels, L., Bouillon, R., Verstuyf, A. Cancer Res. (2007)
- BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Yarden, R.I., Pardo-Reoyo, S., Sgagias, M., Cowan, K.H., Brody, L.C. Nat. Genet. (2002)
- MDC1 is a mediator of the mammalian DNA damage checkpoint. Stewart, G.S., Wang, B., Bignell, C.R., Taylor, A.M., Elledge, S.J. Nature (2003)
- Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Furnari, B., Rhind, N., Russell, P. Science (1997)
- Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Peng, C.Y., Graves, P.R., Thoma, R.S., Wu, Z., Shaw, A.S., Piwnica-Worms, H. Science (1997)
- Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine. Mesa, R.A., Loegering, D., Powell, H.L., Flatten, K., Arlander, S.J., Dai, N.T., Heldebrant, M.P., Vroman, B.T., Smith, B.D., Karp, J.E., Eyck, C.J., Erlichman, C., Kaufmann, S.H., Karnitz, L.M. Blood (2005)
- Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells. Hirose, Y., Berger, M.S., Pieper, R.O. Cancer Res. (2001)
- Geldanamycin-induced degradation of Chk1 is mediated by proteasome. Nomura, M., Nomura, N., Yamashita, J. Biochem. Biophys. Res. Commun. (2005)
- A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation. Xiao, Z., Xue, J., Sowin, T.J., Rosenberg, S.H., Zhang, H. Oncogene (2005)
- Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells. Laezza, C., Simona Pisanti, n.u.l.l., Crescenzi, E., Bifulco, M. FEBS Lett. (2006)
- SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Jin, J., Shirogane, T., Xu, L., Nalepa, G., Qin, J., Elledge, S.J., Harper, J.W. Genes Dev. (2003)
- PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Lu, X., Nannenga, B., Donehower, L.A. Genes Dev. (2005)
- Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. Rocha, S., Garrett, M.D., Campbell, K.J., Schumm, K., Perkins, N.D. EMBO J. (2005)
- Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Liu, S., Bekker-Jensen, S., Mailand, N., Lukas, C., Bartek, J., Lukas, J. Mol. Cell. Biol. (2006)
- An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage. Heffernan, T.P., Simpson, D.A., Frank, A.R., Heinloth, A.N., Paules, R.S., Cordeiro-Stone, M., Kaufmann, W.K. Mol. Cell. Biol. (2002)
- Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains. Ng, C.P., Lee, H.C., Ho, C.W., Arooz, T., Siu, W.Y., Lau, A., Poon, R.Y. J. Biol. Chem. (2004)
- The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe. Castedo, M., Perfettini, J.L., Roumier, T., Yakushijin, K., Horne, D., Medema, R., Kroemer, G. Oncogene (2004)
- DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. Clarke, C.A., Clarke, P.R. Biochem. J. (2005)
- Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes. Flaggs, G., Plug, A.W., Dunks, K.M., Mundt, K.E., Ford, J.C., Quiggle, M.R., Taylor, E.M., Westphal, C.H., Ashley, T., Hoekstra, M.F., Carr, A.M. Curr. Biol. (1997)
- Nbs1 is required for ATR-dependent phosphorylation events. Stiff, T., Reis, C., Alderton, G.K., Woodbine, L., O'Driscoll, M., Jeggo, P.A. EMBO J. (2005)
- Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites. Das, K.C., Dashnamoorthy, R. Am. J. Physiol. Lung Cell Mol. Physiol. (2004)
- p53 down-regulates CHK1 through p21 and the retinoblastoma protein. Gottifredi, V., Karni-Schmidt, O., Shieh, S.S., Prives, C. Mol. Cell. Biol. (2001)
- Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control. Demidova, A.R., Aau, M.Y., Zhuang, L., Yu, Q. J. Biol. Chem. (2009)
- Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Alderton, G.K., Galbiati, L., Griffith, E., Surinya, K.H., Neitzel, H., Jackson, A.P., Jeggo, P.A., O'Driscoll, M. Nat. Cell Biol. (2006)
- Cdc7-Dbf4 and the Human S Checkpoint Response to UVC. Heffernan, T.P., Unsal-Kaçmaz, K., Heinloth, A.N., Simpson, D.A., Paules, R.S., Sancar, A., Cordeiro-Stone, M., Kaufmann, W.K. J. Biol. Chem. (2007)
- Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress. Arlander, S.J., Eapen, A.K., Vroman, B.T., McDonald, R.J., Toft, D.O., Karnitz, L.M. J. Biol. Chem. (2003)
- Characterization of the 5'flanking region of the human Chk1 gene: identification of E2F1 functional sites. Carrassa, L., Broggini, M., Vikhanskaya, F., Damia, G. Cell Cycle (2003)
- Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling. Yan, S., Lindsay, H.D., Michael, W.M. J. Cell Biol. (2006)
- The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Shieh, S.Y., Ahn, J., Tamai, K., Taya, Y., Prives, C. Genes Dev. (2000)
- CHK1 kinase activity assay. Wang, Y., Wang, H. Methods Mol. Biol. (2004)
- Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. Groth, A., Lukas, J., Nigg, E.A., Silljé, H.H., Wernstedt, C., Bartek, J., Hansen, K. EMBO J. (2003)
- Inhibition of Chk1 by activated PKB/Akt. King, F.W., Skeen, J., Hay, N., Shtivelman, E. Cell Cycle (2004)
- ATM-dependent CHK2 activation induced by anticancer agent, irofulven. Wang, J., Wiltshire, T., Wang, Y., Mikell, C., Burks, J., Cunningham, C., Van Laar, E.S., Waters, S.J., Reed, E., Wang, W. J. Biol. Chem. (2004)
- Human claspin is required for replication checkpoint control. Chini, C.C., Chen, J. J. Biol. Chem. (2003)
- The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint. Ho, C.C., Siu, W.Y., Chow, J.P., Lau, A., Arooz, T., Tong, H.Y., Ng, I.O., Poon, R.Y. Exp. Cell Res. (2005)
- The human decatenation checkpoint. Deming, P.B., Cistulli, C.A., Zhao, H., Graves, P.R., Piwnica-Worms, H., Paules, R.S., Downes, C.S., Kaufmann, W.K. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. Xu, X., Lee, J., Stern, D.F. J. Biol. Chem. (2004)
- Cleavage-mediated activation of Chk1 during apoptosis. Matsuura, K., Wakasugi, M., Yamashita, K., Matsunaga, T. J. Biol. Chem. (2008)
- ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Zhao, H., Piwnica-Worms, H. Mol. Cell. Biol. (2001)
- The DNA double-strand break response pathway: becoming more BRCAish than ever. Ting, N.S., Lee, W.H. DNA Repair (Amst.) (2004)
- Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Krämer, A., Mailand, N., Lukas, C., Syljuåsen, R.G., Wilkinson, C.J., Nigg, E.A., Bartek, J., Lukas, J. Nat. Cell Biol. (2004)
- The Involvement of Ataxia-telangiectasia Mutated Protein Activation in Nucleotide Excision Repair-facilitated Cell Survival with Cisplatin Treatment. Colton, S.L., Xu, X.S., Wang, Y.A., Wang, G. J. Biol. Chem. (2006)