High impact information on Cat3

• The ak, Cat3 and Cat2 mutants are discussed in the context of other mutants affecting early eye and lens development [1].
• Two mutant alleles of the Cat3 locus have been mapped to mouse chromosome 10 very close to the microsatellite markers D10Mit41 and D10Mit95 (less than 0.3 cM) [1].
• Since Cat3 is mapped to a position, which is homologous to human chromosome 12q21-24, the disorder cornea plana congenita can be considered as a candidate disease [1].
• The Cat3 mutations are characterized by vacuolated lenses caused by alterations in the beginning of secondary lens fiber cell differentiation at embryonic day 12 [1].
• Therefore, Tr2-11 was excluded as a candidate for the Cat3 mutation [2].

Associations of Cat3 with chemical compounds

• The majority of L-arginine flux is mediated by transport system y+ that is encoded by at least three genes, Cat1, Cat2 and Cat3 [3].

Analytical, diagnostic and therapeutic context of Cat3

• Since the dominant cataract mutation Cat3 was mapped very closely to the murine nuclear receptor TR2-11 gene locus, the corresponding coding region was amplified by PCR using either genomic DNA or eye-derived cDNA of wild-type (C3Hx102)F1 and of homozygous Cat3 cataract animals [2].

References