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Gene Review

Cat3  -  dominant cataract 3

Mus musculus

Synonyms: Cat-3, Vlm, vacuolated lens with microphthalmia
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High impact information on Cat3

  • The ak, Cat3 and Cat2 mutants are discussed in the context of other mutants affecting early eye and lens development [1].
  • Two mutant alleles of the Cat3 locus have been mapped to mouse chromosome 10 very close to the microsatellite markers D10Mit41 and D10Mit95 (less than 0.3 cM) [1].
  • Since Cat3 is mapped to a position, which is homologous to human chromosome 12q21-24, the disorder cornea plana congenita can be considered as a candidate disease [1].
  • The Cat3 mutations are characterized by vacuolated lenses caused by alterations in the beginning of secondary lens fiber cell differentiation at embryonic day 12 [1].
  • Therefore, Tr2-11 was excluded as a candidate for the Cat3 mutation [2].

Associations of Cat3 with chemical compounds

  • The majority of L-arginine flux is mediated by transport system y+ that is encoded by at least three genes, Cat1, Cat2 and Cat3 [3].

Analytical, diagnostic and therapeutic context of Cat3

  • Since the dominant cataract mutation Cat3 was mapped very closely to the murine nuclear receptor TR2-11 gene locus, the corresponding coding region was amplified by PCR using either genomic DNA or eye-derived cDNA of wild-type (C3Hx102)F1 and of homozygous Cat3 cataract animals [2].


  1. Cataract mutations and lens development. Graw, J. Progress in retinal and eye research. (1999) [Pubmed]
  2. Polymorphism in the murine Tr2-11 gene encoding an orphan receptor, and its exclusion as a candidate gene for the cataract mutation Cat3. Immervoll, T., Adamski, J., Graw, J. Biol. Chem. (1998) [Pubmed]
  3. Stress differentially induces cationic amino acid transporter gene expression. Kakuda, D.K., Finley, K.D., Maruyama, M., MacLeod, C.L. Biochim. Biophys. Acta (1998) [Pubmed]
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