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Gene Review:

Ly23 - lymphocyte antigen 23

Mus musculus

Synonyms: Ly-23

Cantor, H. et al., Gasser, D.L. et al., Jandinski, J. et al., Newcomb, E.W. et al., Stutman, O. et al., et al.

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Disease relevance of Ly23

MSF impairs only the activity of cells mediating contact sensitivity reaction (Ly 1) but has no influence on T-suppressor cells (Ly 23) [1].

High impact information on Ly23

Mice of the HRS strain, which carry the mutant gene hr, were examined for abnormalities in representation of the three T-cell sets Ly1, Ly23, and Ly123 in the spleen [2].
Concanavalin A, a nonspecific polyclonal activator of T lymphocytes, activates Lyl and Ly23 subclasses to the same degree [3].
It remains to be determined whether killing and suppression are functionally interrelated properties of a single Ly23 subclass, or whether the Ly23 population comprises two subclasses whose surface phenotypes are not yet distinguishable by immunogenetic criteria [4].
After activation, the Ly23 subclass, but not the Lyl subclass, has the following properties: (a) Suppression of the antibody response to sheep erythrocytes (SRBC) in vitro [3].
Suppression by Ly23 cells is specific, because Ly23 cells from SRBC-primed animals do not suppress the response to horse erythrocytes, and vice versa [4].

Biological context of Ly23

A monoclonal antibody has been developed that recognizes a mouse lymphocyte antigen, Ly-23, that is controlled by an H-3 histocompatibility complex-linked gene on the second chromosome [5].
The T-cell population of these "B-Ly1" and "B-Ly23" mice mice also remains restricted to the Ly1 and Ly23 subclass phenotypes [6].

Anatomical context of Ly23

It appears, therefore, that maximal CMC is achieved by the participation of specific Ly123 cells which in the late phase directly or indirectly give rise to Ly23 killer cells [7].

Other interactions of Ly23

However, the R1E/TL8X line of cells, which lacks beta 2-microglobulin, is negative for the Ly-23 antigen, although the control R1.1 line is positive [5].
Most other cell surface antigens examined were minimally affected by IFN-alpha/beta with the exception of Ly-11 and Ly-23 [8].

Analytical, diagnostic and therapeutic context of Ly23

Thymectomy of mice aged 6-8 weeks causes a disproportion of splenic T cell sets, the Ly123 set being relatively decreased and the Ly23 set relatively increased (Ly123 decrease: Ly23 increase) [9].

References

Macrophage suppressor factor in contact sensitivity. Mechanisms of its release and action. Marcinkiewicz, J., Ptak, W. Immunology (1980) [Pubmed]
Disproportion in T-cell subpopulations in immunodeficient mutant hr/hr mice. Reske-Kunz, A.B., Scheid, M.P., Boyse, E.A. J. Exp. Med. (1979) [Pubmed]
Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses. Jandinski, J., Cantor, H., Tadakuma, T., Peavy, D.L., Pierce, C.W. J. Exp. Med. (1976) [Pubmed]
Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses. Cantor, H., Shen, F.W., Boyse, E.A. J. Exp. Med. (1976) [Pubmed]
A lymphocyte antigen encoded by a locus closely linked to H-3 on the second chromosome of the mouse. Gasser, D.L., Ziebur, J., Matsumoto, K. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
Independent differentiative pathways of Ly1 and Ly23 subclasses of T cells. Experimental production of mice deprived of selected T-cell subclasses. Huber, B., Cantor, H., Shen, F.W., Boyse, E.A. J. Exp. Med. (1976) [Pubmed]
Ly phenotype of T cells cytotoxic for syngeneic mouse mammary tumors: evidence for T cell interactions. Stutman, O., Shen, F.W., Boyse, E.A. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
Phenotypic changes induced by interferon in resting T cells: major enhancement of Ly-6 antigen expression. Dumont, F.J., Palfree, R.G., Coker, L.Z. J. Immunol. (1986) [Pubmed]
Regulatory influence of thymopentin on splenic T cell sets of thymectomized and aged mice. Newcomb, E.W., Goldberg, E.H., de Sousa, M., Goldstein, G., Boyse, E.A., Scheid, M.P. Transplantation (1985) [Pubmed]

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