High impact information on TMED1

• We show for the first time that ST2L and IL-18R are stable selective cell surface markers for human Th2/Tc2/NK2 and Th1/Tc1/NK1 lymphocytes, respectively [1].
• Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes [1].
• Recently, we reported that ST2L and IL-18R are stably expressed on murine Th2 and Th1 cells, respectively [1].
• No expression of ST2L or ST2 mRNA was detected in any of the resting T cell subsets [2].
• Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface [2].

Anatomical context of TMED1

• These findings taken together, indicate that ST2V protein localizes on the plasma membrane, suggesting its possible role in modification of the ST2L-signaling pathways [3].
• After adding different cryoprotectants, the median temperature of IIF (TMED) was decreased by approximately 23 degrees C in mouse and only by approximately 6.5 degrees C in human oocytes [4].

References