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Gene Review

Shroom2  -  shroom family member 2

Mus musculus

Synonyms: 4832440C16, Apxl, C630003H05Rik, Protein Apxl, Protein Shroom2, ...
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High impact information on Shroom2

  • In fibroblasts, Shroom readily associates with actin stress fibers and induces bundling, Apxl is found on cortical actin, and KIAA1202 is localized to a cytoplasmic population of F-actin [1].
  • Finally, we show that Apxl is involved in regulating the cytoskeletal organization and architecture of endothelial cells [1].
  • Shroom, Apxl, and KIAA1202 exhibit differing abilities to interact with the actin cytoskeleton [1].
  • In epithelial cells, Apxl and KIAA1202 do not induce apical constriction as Shroom does, but have the capacity to do so if targeted to the apical junctional complex [1].
  • The mouse homologues, Oa1 and Apxl, have recently been shown to lie proximal to their expected locations on the mouse X chromosome, but their positions with respect to critical gene loci in the vicinity have not been defined [2].


  1. Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins. Dietz, M.L., Bernaciak, T.M., Vendetti, F., Kielec, J.M., Hildebrand, J.D. J. Biol. Chem. (2006) [Pubmed]
  2. An integrated genetic and man-mouse comparative map of the DXHXS674-Pdha1 region of the mouse X chromosome. Blair, H.J., Uwechue, I.C., Barsh, G.S., Rowe, P.S., Boyd, Y. Genomics (1998) [Pubmed]
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