High impact information on Shroom2

• In fibroblasts, Shroom readily associates with actin stress fibers and induces bundling, Apxl is found on cortical actin, and KIAA1202 is localized to a cytoplasmic population of F-actin [1].
• Finally, we show that Apxl is involved in regulating the cytoskeletal organization and architecture of endothelial cells [1].
• Shroom, Apxl, and KIAA1202 exhibit differing abilities to interact with the actin cytoskeleton [1].
• In epithelial cells, Apxl and KIAA1202 do not induce apical constriction as Shroom does, but have the capacity to do so if targeted to the apical junctional complex [1].
• The mouse homologues, Oa1 and Apxl, have recently been shown to lie proximal to their expected locations on the mouse X chromosome, but their positions with respect to critical gene loci in the vicinity have not been defined [2].

References