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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SHROOM2  -  shroom family member 2

Homo sapiens

Synonyms: APXL, Apical-like protein, HSAPXL, Protein APXL, Protein Shroom2
 
 
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High impact information on SHROOM2

  • The gene, termed APXL (APX-Like), spans approximately 160 kb, contains 10 exons and covers over 70% of the 110 kb critical region for OA1 [1].
  • Mapping, expression and patient analysis data led us to consider the APXL gene a strong candidate for the OA1 gene [1].
  • Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium [2].
  • Here, we show that the Shroom-family protein, Shroom2 (previously known as APXL) is both necessary and sufficient to govern the localization of pigment granules at the apical surface of epithelial cells [2].
  • The molecular mechanism underlying the regulation of the expression of Apxl, the gene encoding cytosolic ascorbate peroxidase, as well as other antioxidant enzymes, was studied during the progression of drought stress and following recovery from drought [3].
 

Other interactions of SHROOM2

References

  1. Cloning of a human homologue of the Xenopus laevis APX gene from the ocular albinism type 1 critical region. Schiaffino, M.V., Bassi, M.T., Rugarli, E.I., Renieri, A., Galli, L., Ballabio, A. Hum. Mol. Genet. (1995) [Pubmed]
  2. Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium. Fairbank, P.D., Lee, C., Ellis, A., Hildebrand, J.D., Gross, J.M., Wallingford, J.B. Development (2006) [Pubmed]
  3. Regulation of pea cytosolic ascorbate peroxidase and other antioxidant enzymes during the progression of drought stress and following recovery from drought. Mittler, R., Zilinskas, B.A. Plant J. (1994) [Pubmed]
  4. A new standard nomenclature for proteins related to Apx and Shroom. Hagens, O., Ballabio, A., Kalscheuer, V., Kraehenbuhl, J.P., Schiaffino, M.V., Smith, P., Staub, O., Hildebrand, J., Wallingford, J.B. BMC Cell Biol. (2006) [Pubmed]
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