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DUS4L  -  dihydrouridine synthase 4-like (S....

Homo sapiens

Synonyms: DUS4, PP35, pp35, tRNA-dihydrouridine synthase 4-like
 
 
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High impact information on DUS4L

  • PP35 (but not PP33) was immunoprecipitated by an antibody to phosducin, a PKA-regulated modulator of phototransduction (Lee et al., 1992); PP35 was also phosphorylated in vitro by a Ca2+ calmodulin-activated kinase [1].
  • PP33 further differed from PP35 in its phosphopeptide maps and phosphorylation by PKC [1].
  • Candidate mediator proteins include PP35, a fish phosducin homolog, and PP33, a newly described photoreceptor phosphoprotein [1].
  • One, at 35 kDa, comigrated with a second cAMP-stimulated RIS-ROS phosphoprotein, PP35, which was also detected in the cytoskeleton [2].
  • The PP35 MAb induced activation of essentially all NK cells, although clonal analysis revealed quantitative differences in the magnitude of the cytolytic responses elicited in different clones [3].

References

  1. Phosducin and PP33 are in vivo targets of PKA and type 1 or 2A phosphatases, regulators of cell elongation in teleost rod inner-outer segments. Pagh-Roehl, K., Lin, D., Su, L., Burnside, B. J. Neurosci. (1995) [Pubmed]
  2. Identification of cyclic nucleotide-regulated phosphoproteins, including phosducin, in motile rod inner-outer segments of teleosts. Pagh-Roehl, K., Han, E., Burnside, B. Exp. Eye Res. (1993) [Pubmed]
  3. Novel surface molecules involved in human NK cell activation and triggering of the lytic machinery. Moretta, A., Bottino, C., Tripodi, G., Vitale, M., Pende, D., Morelli, L., Augugliaro, R., Barbaresi, M., Ciccone, E., Millo, R. Int. J. Cancer Suppl. (1992) [Pubmed]
 
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