Gene Review:
PDC - phosducin
Homo sapiens
Synonyms:
33 kDa phototransducing protein, MEKA, PHD, PhLOP, PhLP, ...
- Altered maturation of circulating dendritic cells in primary progressive MS patients. López, C., Comabella, M., Al-zayat, H., Tintoré, M., Montalban, X. J. Neuroimmunol. (2006)
- Novel environmental toxins: Steryl glycosides as a potential etiological factor for age-related neurodegenerative diseases. Ly, P.T., Singh, S., Shaw, C.A. J. Neurosci. Res. (2007)
- Commentary on: return of the cycad hypothesis - does the amyotrophic lateral sclerosis/Parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health? Cox, P.A., Banack, S., Murch, S., Sacks, O. Neuropathol. Appl. Neurobiol. (2006)
- The paroxysmal dyskinesias. Bhatia, K.P. J. Neurol. (1999)
- Pigmentary retinopathy of ALS/PDC in Kii. Kokubo, Y., Ito, K., Fukunaga, T., Matsubara, H., Kuzuhara, S. Ophthalmology (2006)
- Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia. Sundar, P.D., Yu, C.E., Sieh, W., Steinbart, E., Garruto, R.M., Oyanagi, K., Craig, U.K., Bird, T.D., Wijsman, E.M., Galasko, D.R., Schellenberg, G.D. Hum. Mol. Genet. (2007)
- Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam. Forman, M.S., Schmidt, M.L., Kasturi, S., Perl, D.P., Lee, V.M., Trojanowski, J.Q. Am. J. Pathol. (2002)
- Effects of Tai Chi exercise on physical and mental health of college students. Wang, Y.T., Taylor, L., Pearl, M., Chang, L.S. Am. J. Chin. Med. (2004)
- The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases. Iwase, S., Lan, F., Bayliss, P., de la Torre-Ubieta, L., Huarte, M., Qi, H.H., Whetstine, J.R., Bonni, A., Roberts, T.M., Shi, Y. Cell (2007)
- Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Zhang, Y., Leaves, N.I., Anderson, G.G., Ponting, C.P., Broxholme, J., Holt, R., Edser, P., Bhattacharyya, S., Dunham, A., Adcock, I.M., Pulleyn, L., Barnes, P.J., Harper, J.I., Abecasis, G., Cardon, L., White, M., Burton, J., Matthews, L., Mott, R., Ross, M., Cox, R., Moffatt, M.F., Cookson, W.O. Nat. Genet. (2003)
- MHC class I ubiquitination by a viral PHD/LAP finger protein. Boname, J.M., Stevenson, P.G. Immunity (2001)
- Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta. Jones, D.R., Bultsma, Y., Keune, W.J., Halstead, J.R., Elouarrat, D., Mohammed, S., Heck, A.J., D'Santos, C.S., Divecha, N. Mol. Cell (2006)
- Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis. Van de Water, J., Ansari, A., Prindiville, T., Coppel, R.L., Ricalton, N., Kotzin, B.L., Liu, S., Roche, T.E., Krams, S.M., Munoz, S., Gershwin, M.E. J. Exp. Med. (1995)
- Human monoclonal antibodies from a patient with primary biliary cirrhosis that recognize two distinct autoepitopes in the E2 component of the pyruvate dehydrogenase complex. Matsui, M., Nakamura, M., Ishibashi, H., Koike, K., Kudo, J., Niho, Y. Hepatology (1993)
- Glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipoxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport. Re, D.B., Nafia, I., Melon, C., Shimamoto, K., Goff, L.K., Had-Aissouni, L. Glia (2006)
- Isolation of various forms of sterol beta-D-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS-parkinsonism dementia complex. Khabazian, I., Bains, J.S., Williams, D.E., Cheung, J., Wilson, J.M., Pasqualotto, B.A., Pelech, S.L., Andersen, R.J., Wang, Y.T., Liu, L., Nagai, A., Kim, S.U., Craig, U.K., Shaw, C.A. J. Neurochem. (2002)
- Damage and repair of nerve cell DNA in toxic stress. Kisby, G.E., Kabel, H., Hugon, J., Spencer, P. Drug Metab. Rev. (1999)
- Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. Appelhoff, R.J., Tian, Y.M., Raval, R.R., Turley, H., Harris, A.L., Pugh, C.W., Ratcliffe, P.J., Gleadle, J.M. J. Biol. Chem. (2004)
- Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2. Ruiz-Gómez, A., Humrich, J., Murga, C., Quitterer, U., Lohse, M.J., Mayor, F. J. Biol. Chem. (2000)
- PhLPs and PhLOPs in the phosducin family of G beta gamma binding proteins. Craft, C.M., Xu, J., Slepak, V.Z., Zhan-Poe, X., Zhu, X., Brown, B., Lolley, R.N. Biochemistry (1998)
- Regulation of exocytosis in chromaffin cells by phosducin-like protein, a protein interacting with G protein betagamma subunits. Gensse, M., Vitale, N., Chasserot-Golaz, S., Bader, M.F. FEBS Lett. (2000)
- Phosducin, potential role in modulation of olfactory signaling. Boekhoff, I., Touhara, K., Danner, S., Inglese, J., Lohse, M.J., Breer, H., Lefkowitz, R.J. J. Biol. Chem. (1997)
- Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling. Hawes, B.E., Touhara, K., Kurose, H., Lefkowitz, R.J., Inglese, J. J. Biol. Chem. (1994)
- Assignment of the phosducin (PDC) gene to human chromosome 1q25-1q32.1 by somatic cell hybridization and in situ hybridization. Sparkes, R.S., Lee, R.H., Shinohara, T., Craft, C.M., Kojis, T., Klisak, I., Heinzmann, C., Bateman, J.B. Genomics (1993)
- Isolation and analysis of the human MEKA gene encoding a retina-specific protein. Watanabe, Y., Kawasaki, K., Miki, N., Kuo, C.H. Biochem. Biophys. Res. Commun. (1990)
- Cooperative induction of a tolerogenic dendritic cell phenotype by cytokines secreted by pancreatic carcinoma cells. Bellone, G., Carbone, A., Smirne, C., Scirelli, T., Buffolino, A., Novarino, A., Stacchini, A., Bertetto, O., Palestro, G., Sorio, C., Scarpa, A., Emanuelli, G., Rodeck, U. J. Immunol. (2006)
- Phosducin and phosducin-like protein attenuate G-protein-coupled receptor-mediated inhibition of voltage-gated calcium channels in rat sympathetic neurons. Partridge, J.G., Puhl, H.L., Ikeda, S.R. Mol. Pharmacol. (2006)
- Proteomic Analysis of the Genotoxicant Methylazoxymethanol (MAM)-Induced Changes in the Developing Cerebellum. Kisby, G.E., Standley, M., Park, T., Olivas, A., Fei, S., Jacob, T., Reddy, A., Lu, X., Pattee, P., Nagalla, S.R. J. Proteome Res. (2006)
- Identification of possible phosducins in the ciliate Blepharisma japonicum. Fabczak, H., Sobierajska, K., Fabczak, S. Protist (2004)
- Presence of phosducin in the nuclei of bovine retinal cells. Margulis, A., Dang, L., Pulukuri, S., Lee, R., Sitaramayya, A. Mol. Vis. (2002)
- Immunohistochemical study of the hippocampus in parkinsonism-dementia complex on Guam. Ito, H., Goto, S., Hirano, A., Yen, S.H. Journal of geriatric psychiatry and neurology. (1991)
- Interactions of phosducin with the subunits of G-proteins. Binding to the alpha as well as the betagamma subunits. Bauer, P.H., Blüml, K., Schröder, S., Hegler, J., Dees, C., Lohse, M.J. J. Biol. Chem. (1998)
- Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in beta-tubulin. Yoshida, N., Haga, K., Haga, T. Eur. J. Biochem. (2003)
- Phosducin inhibits receptor phosphorylation by the beta-adrenergic receptor kinase in a PKA-regulated manner. Hekman, M., Bauer, P.H., Söhlemann, P., Lohse, M.J. FEBS Lett. (1994)
- The gene for human phosducin (PDC), a soluble protein that binds G-protein beta gamma dimers, maps to 1q25-q31.1. Ding, C., Li, X., Griffin, C.A., Jabs, E.W., Hawkins, A.L., Levine, M.A. Genomics (1993)
- Mutation screening of the phosducin gene PDC in patients with retinitis pigmentosa and allied diseases. Nishiguchi, K.M., Berson, E.L., Dryja, T.P. Mol. Vis. (2004)
- Differential dysfunction in dendritic cell subsets during chronic HCV infection. Averill, L., Lee, W.M., Karandikar, N.J. Clin. Immunol. (2007)
- Molecular cloning and characterization of the human phosducin-like protein (hPhLP) promoter. Lazarov, M.E., Martin, M.M., Willardson, B.M., Elton, T.S. Biochim. Biophys. Acta (2000)