Disease relevance of hepA

• In Anabaena spp., synthesis of the heterocyst envelope polysaccharide, required if the cell is to fix dinitrogen under aerobic conditions, is dependent on the gene hepA [1].

High impact information on hepA

• HetR binds the promoter regions of hetR, hepA, and patS, suggesting a direct control of the expression of these genes by HetR [2].
• Insertional mutagenesis of abp2 and abp3 blocked expression of hepC and hepA and prevented heterocyst maturation and aerobic fixation of N(2) [3].
• A hepK mutation blocked both the synthesis of the heterocyst envelope polysaccharide and induction of hepA [1].
• Inactivation of hepC led to constitutive expression of hepA and prevented the synthesis of heterocyst envelope polysaccharide [1].
• Analysis of the region between hepC and hepA indicated that DNA sequences required for the induction of hepA upon nitrogen deprivation are present between bp -574 and -440 and between bp -340 and -169 relative to the transcriptional start site of hepA [1].

Other interactions of hepA

• Regulation of hepA of Anabaena sp. strain PCC 7120 by elements 5' from the gene and by hepK [1].

References