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Gene Review:

PTPN21 - protein tyrosine phosphatase, non-receptor...

Homo sapiens

Synonyms: PTPD1, PTPRL10, Protein-tyrosine phosphatase D1, Tyrosine-protein phosphatase non-receptor type 21

Jui, H.Y. et al., Zeitlin, A.A. et al., Møller, N.P. et al., Warabi, M. et al.

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Disease relevance of PTPN21

Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease [1].

High impact information on PTPN21

A 6.2-kb full-length clone encoding a distinct protein-tyrosine phosphatase (PTP; EC 3.1.3.48), PTPD1, was isolated from a human skeletal muscle cDNA library [2].
Taken together, these findings indicate that PTPD1 can selectively associate with and stimulate Tec family kinases and modulate Stat3 activation [3].
Furthermore, the Etk-PTPD1 interaction stimulated the kinase activity of Etk, resulting in an increased phosphotyrosine content in both factors [3].
PTPN21 is another member of the PTPN family and its gene PTPN21 maps to the first reported region of genetic linkage to GD, GD-1, on chromosome 14q31 [1].
PTPD1 did not show any significant trend in comparisons of cancer and surrounding normal mucosa [4].

Other interactions of PTPN21

Significant signals were obtained for three kinds of PTPs, PTP1B, PTPH1, and PTPD1 [4].

Analytical, diagnostic and therapeutic context of PTPN21

Northern blot analyses indicate that PTPD1 and PTPD2 are expressed in a variety of tissues [2].

References

Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. Zeitlin, A.A., Heward, J.M., Brand, O.J., Newby, P.R., Franklyn, J.A., Gough, S.C., Simmonds, M.J. Clin. Endocrinol. (Oxf) (2006) [Pubmed]
Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain. Møller, N.P., Møller, K.B., Lammers, R., Kharitonenkov, A., Sures, I., Ullrich, A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases. Jui, H.Y., Tseng, R.J., Wen, X., Fang, H.I., Huang, L.M., Chen, K.Y., Kung, H.J., Ann, D.K., Shih, H.M. J. Biol. Chem. (2000) [Pubmed]
Expression of protein tyrosine phosphatases and its significance in esophageal cancer. Warabi, M., Nemoto, T., Ohashi, K., Kitagawa, M., Hirokawa, K. Exp. Mol. Pathol. (2000) [Pubmed]

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