The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

Table of contents

About

Terms

 

Gene Review: 

Odc-rs3  -  ornithine decarboxylase, related sequence 3

Mus musculus

Synonyms: BRS-3, Odc-3
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Odc-rs3

  • However, the origin of obesity in BRS-3 knockout (KO) mice remains unclear [1].
 

High impact information on Odc-rs3

  • We previously reported that mice lacking bombesin receptor subtype-3 (BRS-3) exhibit mild late-onset obesity and glucose intolerance [Nature 390 (1997) 160] [2].
  • Although islet insulin contents and the size and number of islets of Langerhans in BRS-3-deficient mice decreased, there was no difference in glucose-stimulated insulin release and proinsulin biosynthesis between BRS-3-deficient and wild-type control mice [2].
  • We concluded that impaired glucose metabolism observed in BRS-3-deficient mice was mainly caused by impaired GLUT4 translocation in adipocytes [2].
  • The suppression values of food intake in BRS-3-deficient, KK-Ay, db/db mice and Zucker obese rat were 49.8+/-5.8%, 16.1+/-4.7%, 0.1+/-2.8% and -2.0+/-2.2% (mean +/- S.E.), respectively [3].

References

  1. Bombesin receptor subtype-3 modulates plasma insulin concentration. Matsumoto, K., Yamada, K., Wada, E., Hasegawa, T., Usui, Y., Wada, K. Peptides (2003) [Pubmed]
  2. Functions of pancreatic beta cells and adipocytes in bombesin receptor subtype-3-deficient mice. Nakamichi, Y., Wada, E., Aoki, K., Ohara-Imaizumi, M., Kikuta, T., Nishiwaki, C., Matsushima, S., Watanabe, T., Wada, K., Nagamatsu, S. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  3. Sibutramine sensitivity assay revealed a unique phenotype of bombesin BB3 receptor-deficient mice. Matsumoto, K., Iijima, H. Eur. J. Pharmacol. (2003) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities