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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ADAMTS6  -  ADAM metallopeptidase with thrombospondin...

Homo sapiens

Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 6, ADAM-TS 6, ADAM-TS6, ADAMTS-6
 
 
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High impact information on ADAMTS6

  • Analysis of full length ADAMTS6 transcript reveals alternative splicing and a role for the 5' untranslated region in translational control [1].
  • The region of the transcript encoding the catalytic domain also contains several notable differences compared to the previously published ADAMTS6 cDNA sequence, including a redefinition of the predicted active site motif [1].
  • The 5'UTR contains 11 AUG codons upstream of the predicted ADAMTS6 start codon and potently inhibits translation of a downstream reporter gene [1].
  • Following stimulation with TNFalpha, ADAMTS1, ADAMTS6 and both ADAMTS9 transcripts expressed in ARPE-19 cells showed a potent upregulation [2].
 

Analytical, diagnostic and therapeutic context of ADAMTS6

  • Quantitative RT-PCR showed that the long and short form of the ADAMTS6 ORF are co-expressed in ARPE-19 cells, but the relative levels of the two forms is modulated by TNFalpha [1].

References

  1. Analysis of full length ADAMTS6 transcript reveals alternative splicing and a role for the 5' untranslated region in translational control. Bevitt, D.J., Li, Z., Lindrop, J.L., Barker, M.D., Clarke, M.P., McKie, N. Gene (2005) [Pubmed]
  2. Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFalpha. Bevitt, D.J., Mohamed, J., Catterall, J.B., Li, Z., Arris, C.E., Hiscott, P., Sheridan, C., Langton, K.P., Barker, M.D., Clarke, M.P., McKie, N. Biochim. Biophys. Acta (2003) [Pubmed]
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