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Gene Review:

GPR45 - G protein-coupled receptor 45

Homo sapiens

Synonyms: PSP24, PSP24(ALPHA), PSP24-1, PSP24-alpha, PSP24A

Marchese, A. et al., Alderton, F. et al., Tigyi, G. et al.

Tigyi, Fischer, Baker, Wang, Yue, Nusser, Virag, Zsiros, Liliom, Miller, Parrill,

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High impact information on GPR45

RT - PCR using gene-specific primers showed that HEK 293 cells express EDG2 and PSP24, the latter being a lipid binding GPCR out with the EDG cluster [1].
3, GPR44 to chromosome 11q12-q13.3, and GPR45 to chromosome 2q11 [2].
Both GPR44 and GPR45 are expressed in the central nervous system and periphery [2].
The receptor encoded by GPR45 is the mammalian orthologue of a putative lysophosphatidic acid receptor from Xenopus laevis [2].

Biological context of GPR45

Two PCR products partially encoding novel GPCRs, named GPR44 and GPR45, were discovered and used to isolate the full-length translational open reading frames from a human genomic library [2].

Analytical, diagnostic and therapeutic context of GPR45

Northern blot and RT-PCR results reinforce the coexpression of PSP24 alpha and different members of the EDG1-7 receptors in the same cell [3].

References

Assessment of agonism at G-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells. Alderton, F., Sambi, B., Tate, R., Pyne, N.J., Pyne, S. Br. J. Pharmacol. (2001) [Pubmed]
Discovery of three novel orphan G-protein-coupled receptors. Marchese, A., Sawzdargo, M., Nguyen, T., Cheng, R., Heng, H.H., Nowak, T., Im, D.S., Lynch, K.R., George, S.R., O'dowd, B.F. Genomics (1999) [Pubmed]
Pharmacological characterization of phospholipid growth-factor receptors. Tigyi, G., Fischer, D.J., Baker, D., Wang, D.A., Yue, J., Nusser, N., Virag, T., Zsiros, V., Liliom, K., Miller, D., Parrill, A. Ann. N. Y. Acad. Sci. (2000) [Pubmed]

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GPR45	Bos taurus
GPR45	Canis lupus familiaris
si:dkeyp-118h3.5	Danio rerio
Gpr45	Mus musculus
GPR45	Pan troglodytes
Gpr45	Rattus norvegicus
gpr45	Xenopus (Silurana) tropicalis

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