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Gene Review:

SP140 - SP140 nuclear body protein

Homo sapiens

Synonyms: LYSP100, LYSP100-A, LYSP100-B, LYSp100, Lymphoid-restricted homolog of Sp100, ...

Dent, A.L. et al., Madani, N. et al., Bloch, D.B. et al.

Bloch, de la Monte, Guigaouri, Filippov, Bloch,

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Disease relevance of SP140

One, the nuclear body protein Sp140, was found specifically in all NP cells (n = 12 cell lines tested; P < or = 0.001), and HIV-1 infection induced its partial dispersal from nuclear bodies into cytosolic colocalization with Vif [1].

High impact information on SP140

In addition to SP100 homology regions, one LYSP100 cDNA isoform contains a bromodomain and a PHD/TTC domain, which are present in a variety of transcriptional regulatory proteins [2].
However, a minority of LYSP100 nuclear dots exactly colocalized with PML and SP100 [2].
Although LYSP100 is expressed only in lymphoid cells, LANDs could be visualized in HeLa cells by transfection of a LYSP100 cDNA [2].
The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation [3].

Other interactions of SP140

By immunofluorescence, LYSP100 was localized to nuclear dots that were surprisingly largely nonoverlapping with PML NBs [2].

References

Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1. Madani, N., Millette, R., Platt, E.J., Marin, M., Kozak, S.L., Bloch, D.B., Kabat, D. J. Virol. (2002) [Pubmed]
LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. Dent, A.L., Yewdell, J., Puvion-Dutilleul, F., Koken, M.H., de The, H., Staudt, L.M. Blood (1996) [Pubmed]
Identification and characterization of a leukocyte-specific component of the nuclear body. Bloch, D.B., de la Monte, S.M., Guigaouri, P., Filippov, A., Bloch, K.D. J. Biol. Chem. (1996) [Pubmed]

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