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Gene Review

SP100  -  SP100 nuclear antigen

Homo sapiens

Synonyms: Nuclear autoantigen Sp-100, Nuclear dot-associated Sp100 protein, Speckled 100 kDa
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Disease relevance of SP100

  • Expression of SP100 inhibits the invasion of breast cancer cells and is induced by Interferon-alpha, which has been shown to inhibit the invasion of cancer cells [1].
  • The PML and SP100-containing nuclear bodies (NBs) represent the best-studied example of a defined nuclear substructure the integrity of which is compromised in certain human diseases, including leukemia, neurodegenerative disorders and viral infection [2].
  • Patients suffering from the autoimmune disease primary biliary cirrhosis often produce antibodies against the SP100 protein [3].
  • To assess the contribution of thoracoscopy in the management of SP 100 consecutive patients with persistent or recurrent pneumothorax were treated at our unit by endoscopic procedure between 1992 and 1997 to obtain permanent pleurodesis and to treat the lung lesion responsible for the leak [4].

High impact information on SP100

  • Further, we demonstrate that a naturally occurring splice variant of SP100, here called SP100-HMG, is a member of the high mobility group-1 (HMG-1) protein family and may thus possess DNA-binding potential [5].
  • Here, we show that SP100 binds to members of the heterochromatin protein 1 (HP1) families of non-histone chromosomal proteins [5].
  • Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification [6].
  • In addition to SP100 homology regions, one LYSP100 cDNA isoform contains a bromodomain and a PHD/TTC domain, which are present in a variety of transcriptional regulatory proteins [7].
  • SP100 inhibits ETS1 activity in primary endothelial cells [8].

Biological context of SP100


Anatomical context of SP100

  • We now demonstrate that SP100 expression is upregulated by interferons, which have been shown to be antiangiogenic, in primary endothelial cells [8].
  • SP100 directly antagonizes ETS1-mediated morphological changes in human umbilical vein endothelial cell (HUVEC) network formation and reduces HUVEC migration and invasion [8].
  • ANNA in patients with PBC are mostly directed against SP100; 3. neutrophil granule components are not the ANCA specific antigens in patients with PSC [12].
  • Comparison of FACSCount AF system, Improved Neubauer hemocytometer, Corning 254 photometer, SpermVision, UltiMate and NucleoCounter SP-100 for determination of sperm concentration of boar semen [13].

Associations of SP100 with chemical compounds

  • In this study either early sown (May 1st) or lately sown (June 2nd) corn plants were treated with Phosphorin & Rhizobactrin as biofertilizers and sprayed with six selected foliar nutrients, i.e. Polymex; Greenzit SP100, Greenzit NPK, Potasin-F, Copper sulphate and Ascorbic acid; in mono-, bi-, and/or tri-sequential applications [14].

Physical interactions of SP100


Other interactions of SP100

  • These data demonstrate that SP100 modulates ETS1-dependent biological processes [1].
  • These observations present molecular evidence for an association between the PML/SP100 NBs and the chromatin nuclear compartment [5].
  • These results indicate that NBS1 is recruited into PODs via interaction with SP100 protein [10].

Analytical, diagnostic and therapeutic context of SP100

  • ANA and ANCA were detected using standard protocols, antibodies against the nuclear antigen SP100 were detected by ELISA with recombinant antigen, antibodies against neutrophil alpha-granules were detected by ELISA [12].


  1. SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion. Yordy, J.S., Li, R., Sementchenko, V.I., Pei, H., Muise-Helmericks, R.C., Watson, D.K. Oncogene (2004) [Pubmed]
  2. The PML nuclear bodies: actors or extras? Seeler, J.S., Dejean, A. Curr. Opin. Genet. Dev. (1999) [Pubmed]
  3. Structure and expression of the murine Sp100 nuclear dot gene. Weichenhan, D., Kunze, B., Zacker, S., Traut, W., Winking, H. Genomics (1997) [Pubmed]
  4. Thoracoscopic apical pleurectomy for persisting or recurring pneumothorax. Al-Qudah, A.S. J. Korean Med. Sci. (1998) [Pubmed]
  5. Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. Seeler, J.S., Marchio, A., Sitterlin, D., Transy, C., Dejean, A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification. Seeler, J.S., Marchio, A., Losson, R., Desterro, J.M., Hay, R.T., Chambon, P., Dejean, A. Mol. Cell. Biol. (2001) [Pubmed]
  7. LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. Dent, A.L., Yewdell, J., Puvion-Dutilleul, F., Koken, M.H., de The, H., Staudt, L.M. Blood (1996) [Pubmed]
  8. SP100 inhibits ETS1 activity in primary endothelial cells. Yordy, J.S., Moussa, O., Pei, H., Chaussabel, D., Li, R., Watson, D.K. Oncogene (2005) [Pubmed]
  9. SP100B is a repressor of gene expression. Wilcox, K.W., Sheriff, S., Isaac, A., Taylor, J.L. J. Cell. Biochem. (2005) [Pubmed]
  10. Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein. Naka, K., Ikeda, K., Motoyama, N. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  11. Three-year experience in using total laboratory automation system. Park, J.W., Koo, S.H., Park, B.K., Kwon, G.C. Southeast Asian J. Trop. Med. Public Health (2002) [Pubmed]
  12. Antineutrophil nuclear antibodies (ANNA) in primary biliary cirrhosis: their prevalence and antigen specificity. Orth, T., Gerken, G., Meyer Zum Büschenfelde, K.H., Mayet, W.J. Zeitschrift für Gastroenterologie. (1997) [Pubmed]
  13. Comparison of FACSCount AF system, Improved Neubauer hemocytometer, Corning 254 photometer, SpermVision, UltiMate and NucleoCounter SP-100 for determination of sperm concentration of boar semen. Hansen, C., Vermeiden, T., Vermeiden, J.P., Simmet, C., Day, B.C., Feitsma, H. Theriogenology (2006) [Pubmed]
  14. Effect of sequential applications of foliar nutrients, biofertilizers and sowing dates on the incidence of corn stem borers in Egypt. Mesbah, H.A., Mourad, A.K., el-Nimr, H.M., el-Kady, M.B., Haroun, N.S. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) (2002) [Pubmed]
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