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Gene Review:

ADCY7 - adenylate cyclase 7

Homo sapiens

Synonyms: AC7, ATP pyrophosphate-lyase 7, Adenylate cyclase type 7, Adenylate cyclase type VII, Adenylyl cyclase 7, ...

Hellevuo, K. et al., Hellevuo, K. et al., Sasson, R. et al.

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Disease relevance of ADCY7

A novel form of human adenylyl cyclase (ADCY7) has been discovered in the human erythroleukemia cell line (HEL) [1].

High impact information on ADCY7

In the current study polymerase chain reaction (PCR) techniques coupled with use of human/rodent somatic hybrid panels and a yeast artificial chromosome (YAC) library were used to determine the chromosomal localization of the gene (adcy7) for ADCY7 enzyme [1].
A 251-bp product from the 3' untranslated region of human adcy7 was amplified for PCR mapping and the results localize the adcy7 gene to region 16q12-16q13 of the human genome [1].
This includes the down-regulation of adenylyl cyclase 7 and 9, elevation of cAMP-dependent phosphodiesterase, and the up-regulation of a negative regulator of G-protein signalling (RGS16) that may negate gonadotrophin signalling via guanine nucleotide binding proteins [2].
PCR techniques combined with fluorescently labeled primers were used to amplify two separate tetranucleotide repeat regions [(AACA)n] in the 3' untranslated region of ADCY7 from the genomic DNA of 62 unrelated individuals [3].

Analytical, diagnostic and therapeutic context of ADCY7

When 30 alcoholic and 17 control individuals were compared, no difference was found in the ADCY7 tetranucleotide polymorphism between alcohol-dependent and control groups [3].

References

Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. Hellevuo, K., Berry, R., Sikela, J.M., Tabakoff, B. Hum. Genet. (1995) [Pubmed]
Gonadotrophin-induced gene regulation in human granulosa cells obtained from IVF patients. Modulation of steroidogenic genes, cytoskeletal genes and genes coding for apoptotic signalling and protein kinases. Sasson, R., Rimon, E., Dantes, A., Cohen, T., Shinder, V., Land-Bracha, A., Amsterdam, A. Mol. Hum. Reprod. (2004) [Pubmed]
Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism. Hellevuo, K., Welborn, R., Menninger, J.A., Tabakoff, B. Am. J. Med. Genet. (1997) [Pubmed]

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