Gene Review:
Atu3768 - homospermidine synthase
Agrobacterium fabrum str. C58
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Disease relevance of Atu3768
- The hss gene from Rhodopseudomonas viridis was placed under the control of the cauliflower mosaic virus (CaMV) 35S promoter in Agrobacterium tumefaciens Ti-plasmid in sense and antisense orientation and both hss constructs were transformed into tobacco plants [1].
High impact information on Atu3768
- Since the diamine putrescine is a precursor of homospermidine and nicotine in tobacco, we performed heterologous expression of a bacterial homospermidine synthase gene (hss)in Nicotiana tabacum and determined the effect on free and conjugated polyamine levels [1].
- Homospermidine synthase (HSS) is a branch-point enzyme that links the secondary pathway (pyrrolizidine alkaloids) to primary metabolism (polyamines) [1].
Analytical, diagnostic and therapeutic context of Atu3768
- Expression of the hss gene was verified by "Northern" and "Southern Blot" analysis [1].
References
- Heterologous expression of a bacterial homospermidine synthase gene in transgenic tobacco: effects on the polyamine pathway. Kaiser, A., Sell, S., Hehl, R. Arch. Pharm. (Weinheim) (2002) [Pubmed]
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