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Gene Review:

Sardh - sarcosine dehydrogenase

Rattus norvegicus

Synonyms: SarDH, Sarcosine dehydrogenase, mitochondrial

Cook, R.J. et al., Wittwer, A.J. et al., Cook, R.J. et al., Foster, M.W. et al., Dombrowski, J.J. et al.

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High impact information on Sardh

S-Nitrosylation of SarDH by NO is best rationalized by a novel mechanism involving the covalently bound flavin of the enzyme [1].
The amino acid sequences of the flavin-peptides of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver mitochondria [2].
The flavoenzymes dimethylglycine dehydrogenase (EC 1.5.99.2) and sarcosine dehydrogenase (EC 1.5.99.1) contain covalently bound FAD linked via the 8 alpha-position of the isoalloxazine ring to the imidazole N(3) of a histidine residue (Cook, R. J., Misono, K. S., and Wagner, C. (1984) J. Biol. Chem. 259, 12475-12480) [2].
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics [3].
Sarcosine dehydrogenase and the vital economy of hepatic mitochondria utilizing riboflavin homologs [4].

Associations of Sardh with chemical compounds

The sequence determined for the flavin-peptide from sarcosine dehydrogenase contained 14 amino acid residues Leu-Thr-Ser-Gly-Thr-Thr-Trp-His(flavin)-Thr-Ala-Gly-Leu-Gly-Arg [2].
Dimethylglycine dehydrogenase (EC 1.5.99.2) and sarcosine dehydrogenase (EC 1.5.99.1) are the folate binding proteins of rat liver mitochondria [5].

References

New insights into protein S-nitrosylation. Mitochondria as a model system. Foster, M.W., Stamler, J.S. J. Biol. Chem. (2004) [Pubmed]
The amino acid sequences of the flavin-peptides of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver mitochondria. Cook, R.J., Misono, K.S., Wagner, C. J. Biol. Chem. (1985) [Pubmed]
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics. Wittwer, A.J., Wagner, C. J. Biol. Chem. (1981) [Pubmed]
Sarcosine dehydrogenase and the vital economy of hepatic mitochondria utilizing riboflavin homologs. Dombrowski, J.J., Lambooy, J.P. Int. J. Biochem. (1981) [Pubmed]
Identification of the covalently bound flavin of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver mitochondria. Cook, R.J., Misono, K.S., Wagner, C. J. Biol. Chem. (1984) [Pubmed]

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AgaP_AGAP007123	Anopheles gambiae str. PEST
SARDH	Bos taurus
SARDH	Canis lupus familiaris
sardh	Danio rerio
CG6385	Drosophila melanogaster
SARDH	Gallus gallus
SARDH	Homo sapiens
SARDH	Macaca mulatta
MGG_12421	Magnaporthe oryzae 70-15
Sardh	Mus musculus
SARDH	Pan troglodytes
sardh	Xenopus (Silurana) tropicalis

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