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Gene Review:

CKS2 - CDC28 protein kinase regulatory subunit 2

Homo sapiens

Synonyms: CKS-2, Cyclin-dependent kinases regulatory subunit 2

Demetrick, D.J. et al., Kawakami, K. et al., Lyng, H. et al.

Lyng, Br??vig, Svendsrud, Holm, Kaalhus, Knutstad, Oksefjell, Sundf??r, Kristensen, Stokke, Demetrick, Zhang, Beach,

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High impact information on CKS2

Among the 6 most highly up-regulated genes, CKS2 was the only gene with a significantly greater level of up-regulation in invasive than in superficial BC (p = 0.04) [1].
Partial sequencing of a genomic clone of CKS2 revealed that the open reading frame lies over three exons [2].
It is unlikely that CKS2 is the BCNS tumour suppressor gene [2].
To investigate whether the CKS genes may be altered in human neoplasia, we mapped the chromosome locations of CKS1 and CKS2 by fluorescence in situ hybridization (FISH) [2].
Six fibroblast cell lines isolated from patients with BCNS were demonstrated by FISH to have both copies of CKS2 present [2].

Other interactions of CKS2

Immunohistochemistry data of CKS2 and MSN showed similar relationships to survival [3].

Analytical, diagnostic and therapeutic context of CKS2

To confirm this result, we subjected all 21 BC samples to real-time PCR assay for CKS2 [1].

References

Identification of differentially expressed genes in human bladder cancer through genome-wide gene expression profiling. Kawakami, K., Enokida, H., Tachiwada, T., Gotanda, T., Tsuneyoshi, K., Kubo, H., Nishiyama, K., Takiguchi, M., Nakagawa, M., Seki, N. Oncol. Rep. (2006) [Pubmed]
Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22. Demetrick, D.J., Zhang, H., Beach, D.H. Cytogenet. Cell Genet. (1996) [Pubmed]
Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer. Lyng, H., Br??vig, R.S., Svendsrud, D.H., Holm, R., Kaalhus, O., Knutstad, K., Oksefjell, H., Sundf??r, K., Kristensen, G.B., Stokke, T. BMC Genomics (2006) [Pubmed]

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