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Gene Review

Tgs1  -  trimethylguanosine synthase homolog (S....

Mus musculus

Synonyms: D4Ertd800e, Ncoa6ip, Nuclear receptor coactivator 6-interacting protein, PIMT, PIPMT, ...
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Disease relevance of Tgs1


High impact information on Tgs1

  • The gene encoding this protein, designated PRIP-interacting protein with methyltransferase domain (PIMT), is localized on chromosome 8q11 and spans more than 40 kb [2].
  • PIMT binds S-adenosyl-l-methionine, the methyl donor for methyltransfer reaction, and it also binds RNA, suggesting that it is a putative RNA methyltransferase [2].
  • PIMT mRNA is ubiquitously expressed, with a high level of expression in heart, skeletal muscle, kidney, liver, and placenta [2].
  • Inhibition of PIMT/Tgs1 expression by siRNA in HeLa cells resulted in an increase in the percentage of cells in G2/M phases [3].

Analytical, diagnostic and therapeutic context of Tgs1

  • Using the immunofluorescence localization method, we found that PIMT and PRIP proteins appear colocalized in the nucleus [2].


  1. Protein repair in the brain, proteomic analysis of endogenous substrates for protein L-isoaspartyl methyltransferase in mouse brain. Zhu, J.X., Doyle, H.A., Mamula, M.J., Aswad, D.W. J. Biol. Chem. (2006) [Pubmed]
  2. Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. Zhu, Y., Qi, C., Cao, W.Q., Yeldandi, A.V., Rao, M.S., Reddy, J.K. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus. Enünlü, I., Pápai, G., Cserpán, I., Udvardy, A., Jeang, K.T., Boros, I. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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