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Gene Review

NCOA6  -  nuclear receptor coactivator 6

Homo sapiens

Synonyms: AIB3, ASC-2, ASC2, Activating signal cointegrator 2, Amplified in breast cancer protein 3, ...
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Disease relevance of NCOA6


Psychiatry related information on NCOA6

  • We also noticed that NRC/MASC genes appear to be more strongly associated with mental retardation and autism spectrum disorders [6].
  • The problem of whether rapid-cycling (RC) bipolar disorder is more frequently associated than non-rapid-cycling (NRC) bipolar disorders with thyroid dysfunction was investigated in two groups of 11 women matched for age and therapy [7].
  • METHODS: Review of 40 years of published health studies of the BFD-endemic area of SW Taiwan showed that earlier publications had limited their cancer associations with arsenic levels in artesian well waters and that the reports of Morales et al., NRC, and EPA failed to do so [8].
  • Moreover, persons in the NRC group who perceived high levels of racism (vs. no racism or BRC group) during active speech showed larger increases in blood pressure across postspeech rest, anger recall, and subsequent rest (p = .03) [9].

High impact information on NCOA6


Chemical compound and disease context of NCOA6

  • Vascular endotheliocytes BAE-2 underwent the gradually proceeding cell death until 48 h after reoxygenation (Reox) following 3 h anoxia (Anox), but protected by pre-Anox administration with L-ascorbic acid (Asc)-2-O-phosphate (Asc2P), an autooxidation-resistant Asc derivative, but not by Asc itself [12].
  • These data confirm that bipolar disorder, especially during treatment with lithium, is associated with at least subclinical hypothyroidism, and suggest that RC patients do not differ from NRC patients in the prevalence of spontaneous or lithium-induced thyroid hypofunction [7].
  • Treatment of massive hemorrhage with liposome encapsulated human hemoglobin (NRC) and hydroxyethyl starch (HES) in beagles [13].
  • Anatoxin-a(s) is a guanidine methyl phosphate ester (unprotonated molecular ion equals 252 daltons) isolated from the freshwater cyanobacterium (blue-green alga) Anabaena flos-aquae strain NRC 525-17 [14].
  • In this study the current Nuclear Regulatory Commission (NRC) protocol is used to evaluate the stability of Tuskegee cement/cobalt chloride waste form in the presence of Thiobacillus thiooxidans (T. thiooxidans) [15].

Biological context of NCOA6

  • Further, the association of TRBP with the DNA-dependent protein kinase (DNA-PK) complex and DNA-independent phosphorylation of TRBP C terminus by DNA-PK point to a potential connection between transcriptional control and chromatin architecture regulation [16].
  • These include activating signal cointegrator 2 (ASC-2), a recently isolated transcriptional coactivator molecule, which is amplified in human cancers and stimulates transactivation by nuclear receptors and numerous other transcription factors [17].
  • In this work, we showed that ASC-2 has an indirect, separate binding site for androgen receptor (AR) [1].
  • The activation of granulocyte-specific gene expression is increased with the concerted action of another basic regionleucine zipper factor, CCAAT/enhancer-binding protein (C/EBPalpha), and ASC-2, which function in a cooperative manner [18].
  • Transient transfection studies further confirmed that the LXXLL-binding affinity correlates with TRBP transcriptional activity [19].

Anatomical context of NCOA6


Associations of NCOA6 with chemical compounds

  • These results, along with the previous report in which AR was shown to directly interact with Rb (Yeh, S., Miyamoto, H., Nishimura, K., Kang, H., Ludlow, J., Hsiao, P., Wang, C., Su, C., and Chang C. (1998) Biochem. Biophys. Res. Commun. 248, 361-367), suggest that the AR-ASC-2 interactions in vivo may involve Rb [1].
  • We isolated a nuclear factor (designated ASC-2) with such properties by using the ligand-binding domain of retinoid X receptor as a bait in a yeast two-hybrid screening [24].
  • Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid [18].
  • PIMT (PRIP-interacting protein with methyltransferase domain), an RNA-binding protein with a methyltransferase domain capable of binding S-adenosylmethionine, has been shown previously to interact with nuclear receptor coactivator PRIP (peroxisome proliferator-activated receptor (PPAR)-interacting protein) and enhance its coactivator function [25].
  • As the differential recruitment of TRBP to ERalpha and ERbeta may rely on S884, our finding provides insight into estrogen signaling and may lead to the development of therapeutic receptor-selective peptide antagonists [19].

Physical interactions of NCOA6


Regulatory relationships of NCOA6

  • The interaction between ATF2 and C/EBPalpha in RA-treated cells was enhanced by the ectopic expression of ASC-2 [18].

Other interactions of NCOA6


Analytical, diagnostic and therapeutic context of NCOA6


  1. Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation. Goo, Y.H., Na, S.Y., Zhang, H., Xu, J., Hong, S., Cheong, J., Lee, S.K., Lee, J.W. J. Biol. Chem. (2004) [Pubmed]
  2. Nuclear hormone receptor coregulator: role in hormone action, metabolism, growth, and development. Mahajan, M.A., Samuels, H.H. Endocr. Rev. (2005) [Pubmed]
  3. Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer. Guan, X.Y., Xu, J., Anzick, S.L., Zhang, H., Trent, J.M., Meltzer, P.S. Cancer Res. (1996) [Pubmed]
  4. Analysis of ligand-dependent recruitment of coactivator peptides to RXRbeta in a time-resolved fluorescence resonance energy transfer assay. Stafslien, D.K., Vedvik, K.L., De Rosier, T., Ozers, M.S. Mol. Cell. Endocrinol. (2007) [Pubmed]
  5. Autoantigenic proteins that bind recombinogenic sequences in Epstein-Barr virus and cellular DNA. Sun, R., Spain, T.A., Lin, S.F., Miller, G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  6. The role of neuronal complexes in human x-linked brain diseases. Laumonnier, F., Cuthbert, P.C., Grant, S.G. Am. J. Hum. Genet. (2007) [Pubmed]
  7. Evaluation of thyroid function in patients with rapid-cycling and non-rapid-cycling bipolar disorder. Bartalena, L., Pellegrini, L., Meschi, M., Antonangeli, L., Bogazzi, F., Dell'Osso, L., Pinchera, A., Placidi, G.F. Psychiatry research. (1990) [Pubmed]
  8. Bladder cancer and arsenic exposure: differences in the two populations enrolled in a study in southwest Taiwan. Lamm, S.H., Byrd, D.M., Kruse, M.B., Feinleib, M., Lai, S.H. Biomed. Environ. Sci. (2003) [Pubmed]
  9. Perceived racism and cardiovascular reactivity and recovery to personally relevant stress. Merritt, M.M., Bennett, G.G., Williams, R.B., Edwards, C.L., Sollers, J.J. Health psychology : official journal of the Division of Health Psychology, American Psychological Association. (2006) [Pubmed]
  10. NRC OKs long-delayed survey of human genome diversity. Pennisi, E. Science (1997) [Pubmed]
  11. Radiation exposure from outpatient radioactive iodine (131I) therapy for thyroid carcinoma. Grigsby, P.W., Siegel, B.A., Baker, S., Eichling, J.O. JAMA (2000) [Pubmed]
  12. Cytoprotection of vascular endotheliocytes by phosphorylated ascorbate through suppression of oxidative stress that is generated immediately after post-anoxic reoxygenation or with alkylhydroperoxides. Saitoh, Y., Miwa, N. J. Cell. Biochem. (2004) [Pubmed]
  13. Treatment of massive hemorrhage with liposome encapsulated human hemoglobin (NRC) and hydroxyethyl starch (HES) in beagles. Takaori, M., Fukui, A. Artificial cells, blood substitutes, and immobilization biotechnology. (1996) [Pubmed]
  14. Anatoxin-a(s), a naturally occurring organophosphate, is an irreversible active site-directed inhibitor of acetylcholinesterase (EC Hyde, E.G., Carmichael, W.W. J. Biochem. Toxicol. (1991) [Pubmed]
  15. Stability evaluation of a cement based waste form to microbially induced degradation. Idachaba, M.A., Nyavor, K., Egiebor, N.O., Rogers, R.D. Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA. (2001) [Pubmed]
  16. Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Ko, L., Cardona, G.R., Chin, W.W. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  17. Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Goo, Y.H., Sohn, Y.C., Kim, D.H., Kim, S.W., Kang, M.J., Jung, D.J., Kwak, E., Barlev, N.A., Berger, S.L., Chow, V.T., Roeder, R.G., Azorsa, D.O., Meltzer, P.S., Suh, P.G., Song, E.J., Lee, K.J., Lee, Y.C., Lee, J.W. Mol. Cell. Biol. (2003) [Pubmed]
  18. Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid. Hong, S., Choi, H.M., Park, M.J., Kim, Y.H., Choi, Y.H., Kim, H.H., Choi, Y.H., Cheong, J. J. Biol. Chem. (2004) [Pubmed]
  19. Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. Ko, L., Cardona, G.R., Iwasaki, T., Bramlett, K.S., Burris, T.P., Chin, W.W. Mol. Endocrinol. (2002) [Pubmed]
  20. NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC. Mahajan, M.A., Murray, A., Samuels, H.H. Mol. Cell. Biol. (2002) [Pubmed]
  21. Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor alpha. Chu, R., Lin, Y., Rao, M.S., Reddy, J.K. J. Biol. Chem. (1996) [Pubmed]
  22. Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor. Choi, E., Lee, S., Yeom, S.Y., Kim, G.H., Lee, J.W., Kim, S.W. Mol. Endocrinol. (2005) [Pubmed]
  23. Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell. Hong, S., Lee, M.Y., Cheong, J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  24. A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. Lee, S.K., Anzick, S.L., Choi, J.E., Bubendorf, L., Guan, X.Y., Jung, Y.K., Kallioniemi, O.P., Kononen, J., Trent, J.M., Azorsa, D., Jhun, B.H., Cheong, J.H., Lee, Y.C., Meltzer, P.S., Lee, J.W. J. Biol. Chem. (1999) [Pubmed]
  25. Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation. Misra, P., Qi, C., Yu, S., Shah, S.H., Cao, W.Q., Rao, M.S., Thimmapaya, B., Zhu, Y., Reddy, J.K. J. Biol. Chem. (2002) [Pubmed]
  26. Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2. Lee, S.K., Jung, S.Y., Kim, Y.S., Na, S.Y., Lee, Y.C., Lee, J.W. Mol. Endocrinol. (2001) [Pubmed]
  27. Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase. Ko, L., Chin, W.W. J. Biol. Chem. (2003) [Pubmed]
  28. In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity. Bautista, S., Vallès, H., Walker, R.L., Anzick, S., Zeillinger, R., Meltzer, P., Theillet, C. Clin. Cancer Res. (1998) [Pubmed]
  29. DNA fingerprinting: the NRC report. Lander, E.S. Science (1993) [Pubmed]
  30. Nonmyeloablative iodine-131 anti-B1 radioimmunotherapy as outpatient therapy. Gates, V.L., Carey, J.E., Siegel, J.A., Kaminski, M.S., Wahl, R.L. J. Nucl. Med. (1998) [Pubmed]
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