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Shewanella oneidensis MR-1

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Disease relevance of omcB

  • Genetic complementation of an outer membrane cytochrome omcB mutant of Shewanella putrefaciens MR-1 requires omcB plus downstream DNA [1].

High impact information on omcB

  • This 21-kb fragment does not contain omcA, but it does contain several open reading frames (ORFs) downstream from omcB [1].
  • The results suggest that the DNA downstream of omcB must be present in cis in order to restore Fe(III) reduction, MnO2 reduction, OM cytochrome content, and the localization of OmcA and OmcB to the OM [1].
  • Since OMCB1 continues to express genes immediately downstream from omcB, the lack of expression of this downstream DNA does not explain its phenotype or the need for the large complementing fragment [1].
  • A 14.7-kb DNA fragment, including omcB and 12 kb of downstream DNA, provided only a modest increase in MnO2 reduction and OM cytochrome content, but it fully restored Fe(III) citrate reduction and partially restored FeOOH reduction [1].
  • Similarly, the omcB mutant (OMCB1) grew on fumarate, nitrate, TMAO, and thiosulfate and reduced ferric citrate and FeOOH [2].

Biological context of omcB


Other interactions of omcB

  • Complementation of OMCA1 with a vector (pVK21) that contains omcB but not omcA restored Mn(IV) reduction to levels that were even greater than those of wild-type [4].

Analytical, diagnostic and therapeutic context of omcB

  • Southern blotting and PCR confirmed replacement of the omcA and omcB genes, respectively, and reverse transcription-PCR analysis demonstrated loss of the respective mRNAs, whereas mRNAs for upstream and downstream genes were retained [2].


  1. Genetic complementation of an outer membrane cytochrome omcB mutant of Shewanella putrefaciens MR-1 requires omcB plus downstream DNA. Myers, J.M., Myers, C.R. Appl. Environ. Microbiol. (2002) [Pubmed]
  2. Role for outer membrane cytochromes OmcA and OmcB of Shewanella putrefaciens MR-1 in reduction of manganese dioxide. Myers, J.M., Myers, C.R. Appl. Environ. Microbiol. (2001) [Pubmed]
  3. Molecular dynamics of the Shewanella oneidensis response to chromate stress. Brown, S.D., Thompson, M.R., Verberkmoes, N.C., Chourey, K., Shah, M., Zhou, J., Hettich, R.L., Thompson, D.K. Mol. Cell Proteomics (2006) [Pubmed]
  4. Overlapping role of the outer membrane cytochromes of Shewanella oneidensis MR-1 in the reduction of manganese(IV) oxide. Myers, J.M., Myers, C.R. Lett. Appl. Microbiol. (2003) [Pubmed]
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