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Gene Review

DACH2  -  dachshund family transcription factor 2

Homo sapiens

Synonyms: Dach2, Dachshund homolog 2
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Disease relevance of DACH2

  • The identification of human DACH2 sequences at Xq21 suggests a possible role for this gene in Allan-Herndon syndrome, Miles-Carpenter syndrome, X-linked cleft palate and/or Megalocornea [1].

High impact information on DACH2

  • We identified Dach2 as a Mgn transcriptional repressor whose expression is dramatically reduced in an HDAC-dependent manner in developing aneural myotubes or adult denervated muscle [2].
  • DACH1 plays a role in retinal and pituitary precursor cell proliferation and DACH2 plays a specific role in myogenesis [3].
  • We performed a mutation analysis of POF1B and of another gene previously identified, DACH2, localized approximately 700 kb distal in Xq21, in a cohort of >200 Italian POF patients [4].


  1. Characterization of mouse Dach2, a homologue of Drosophila dachshund. Davis, R.J., Shen, W., Sandler, Y.I., Heanue, T.A., Mardon, G. Mech. Dev. (2001) [Pubmed]
  2. Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade. Tang, H., Goldman, D. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. Wu, K., Yang, Y., Wang, C., Davoli, M.A., D'Amico, M., Li, A., Cveklova, K., Kozmik, Z., Lisanti, M.P., Russell, R.G., Cvekl, A., Pestell, R.G. J. Biol. Chem. (2003) [Pubmed]
  4. Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B. Bione, S., Rizzolio, F., Sala, C., Ricotti, R., Goegan, M., Manzini, M.C., Battaglia, R., Marozzi, A., Vegetti, W., Dalprà, L., Crosignani, P.G., Ginelli, E., Nappi, R., Bernabini, S., Bruni, V., Torricelli, F., Zuffardi, O., Toniolo, D. Hum. Reprod. (2004) [Pubmed]
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